PREVENT: Towards the Prevention of Intracranial Vessel Perforations During Mechanical Thrombectomy – Protocol for a Multicenter Registry Study

Victor Schulze-Zachau^1,2*Nikki Rommers³Hannah Muenger²Mira Katan^3,4Luzia Balmer²Sofie Haniotis²Alex Brehm²Urs Martin Fischer^5,6Marios-Nikos Psychogios^2,3

• ¹Beaumont Hospital, Dublin, Ireland
• ²Universitatsspital Basel, Basel, Switzerland
• ³Universitat Basel, Basel, Switzerland
• ⁴University Hospital of Basel, Basel, Switzerland
• ⁵Inselspital Universitatsspital Bern Universitatsklinik fur Neurologie, Bern, Switzerland
• ⁶Universitat Bern, Bern, Switzerland

Rationale: The increasing use of thrombectomy for acute ischemic stroke highlights the need to better understand its complications. Vessel perforation leading to active intracranial bleeding is a severe complication, associated with poor outcome and a mortality of approximately 50%. The etiology and risk factors for this severe complication remain largely unknown, and there is limited evidence to guide decision-making regarding endovascular hemostatic strategies and the continuation of thrombectomy after perforation. Design: The Perforation EVents during ENdovascular Therapy for acute ischemic stroke (PREVENT) – Registry is an international, multicenter, prospective and retrospective study collecting data on vessel perforations during thrombectomy. The registry aims to include 500 cases of vessel perforation and 500 matched controls without perforation. The collected data will consist of both tabulated data and periprocedural imaging, which is to be analyzed by a central imaging core laboratory. Data will be analyzed using case-control methods, with univariate and multivariate statistical analyses. Objectives: The primary objectives are to (1) identify risk factors for vessel perforation, (2) explore the underlying pathophysiology, (3) develop a classification system for vessel perforations, (4) compare different hemostatic treatment strategies, (5) evaluate the impact of continuing versus aborting thrombectomy after perforation, and (6) propose a safety-optimized thrombectomy technique. Discussion: Given the frequence and hyperacute emergency of vessel perforations, a prospective randomized study is not feasible. This large, international registry provides a robust approach to gather real-world evidence, reducing bias through multicenter data 2 collection and case matching. The results may improve clinical decision-making and patient safety in thrombectomy procedures. Clinical Trial Registration: ClinicalTrials.gov Identifier: NCT06394180.