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ORIGINAL RESEARCH article

Front. Neurol.

Sec. Stroke

Volume 16 - 2025 | doi: 10.3389/fneur.2025.1682520

This article is part of the Research TopicNeurocardiology: The Science of Heart-Brain InteractionsView all 3 articles

The combination of atrial fibrillation and small vessel disease score worsen spontaneous intracerebral hemorrhage outcomes

Provisionally accepted
Yuki  HamadaYuki Hamada1*Takeo  SatoTakeo Sato1Hideki  MatsuokaHideki Matsuoka1Yuka  TsuchimochiYuka Tsuchimochi1Kaishi  KukiharaKaishi Kukihara1Yutaro  KawabataYutaro Kawabata1Kana  IwamotoKana Iwamoto1Go  TakaguchiGo Takaguchi1Yujiro  HiguchiYujiro Higuchi2Hiroshi  TakashimaHiroshi Takashima2
  • 1Kagoshima Medical Center (NHO), Kagoshima, Japan
  • 2Kagoshima Daigaku Daigakuin Ishigaku Sogo Kenkyuka Shinkei Naika Ronenbyogaku, Kagoshima, Japan

The final, formatted version of the article will be published soon.

ABSTRACT Background: This study aimed to examine whether the presence of atrial fibrillation (AF), severity as judged by total small vessel disease (SVD) score, or a combination of these is associated with prognosis and hematoma volume of spontaneous intracerebral hemorrhage (sICH). Methods: This retrospective analysis investigated 608 patients who were admitted within seven days of ICH onset between July 2012 and November 2023. The primary outcome was prognosis at three months after onset according to the modified Rankin Scale (mRS) score. Associations of AF, SVD and a combination of these with outcomes and hematoma volume were examined using univariate analyses, logistic regression analysis, and multiple regression analysis. Results: A total of 608 consecutive patients with sICH were screened, and 330 patients were finally included in the analysis after applying the inclusion and exclusion criteria. Among the 330 patients analyzed, 145 (43.9%) experienced poor outcomes (mRS score 4–6). The presence of AF was independently associated with poor outcome (adjusted OR 4.93, 95%CI 1.72–16.1; p=0.002), whereas total SVD score alone was not. Multiple regression analysis with estimated hematoma volume also showed a significant association with AF (standard partial regression coefficient 0.16; p=0.033), but not with total SVD score. However, a linear trend was observed between the combination of AF and total SVD score severity and poor outcome (total SVD score 0–1 without AF: aOR 1.00, total SVD score 2–4 without AF: 1.44, total SVD score 0–1 with AF: 4.26, total SVD score 2–4 with AF: 7.57; p for trend=0.002). Multiple regression analysis using estimated hematoma volume also showed a synergistic effect of AF and total SVD score severity (standardized regression coefficient 0.14; p=0.032). Conclusions: The presence of AF was associated with poor 3-month outcomes and increased estimated hematoma volume in sICH patients, whereas total SVD score alone was not. The effects of AF and SVD together appear to contribute synergistically to worsened prognosis and increased hematoma volume in sICH patients.

Keywords: Atrial Fibrillation, intracerebral hemorrhage, small vessel disease, functional outcome, Brain-cardiac interaction

Received: 09 Aug 2025; Accepted: 03 Oct 2025.

Copyright: © 2025 Hamada, Sato, Matsuoka, Tsuchimochi, Kukihara, Kawabata, Iwamoto, Takaguchi, Higuchi and Takashima. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Yuki Hamada, sunamushi.elmonkichi@gmail.com

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