ORIGINAL RESEARCH article
Front. Neurol.
Sec. Multiple Sclerosis and Neuroimmunology
Correlation between fatigue and quality of life among patients with neuromyelitis optica in West China
Provisionally accepted
Xiaohui Miao1*
Qi Liu2- 1Henan Provincial People's Hospital, Zhengzhou, China
- 2Zhejiang University School of Medicine Sir Run Run Shaw Hospital, Hangzhou, China
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Objective: To investigate the current status and determinants of fatigue and to examine the relationship between fatigue and quality of life (QOL) in patients with neuromyelitis optica (NMO). Methods: Eligible patients with NMO were assessed with the Fatigue Impact Scale (FIS) and the Chinese version of the Multiple Sclerosis Quality of Life-54 (MSQOL-54). Clinical factors influencing fatigue were explored and the association between fatigue and QOL was analyzed. Results: Sixty-nine patients (mean age 40.13 years, male/female 6/63) were enrolled. The median Expanded Disability Status Scale (EDSS) score was 3, and 75.4 % were seropositive for NMO-IgG. The total FIS score was 67.12 ± 41.24, accounted for by the three sub-dimensions: cognitive fatigue 13.80 ± 9.63, physical fatigue 20.48 ± 12.93, and psychosocial fatigue 32.84 ± 20.94. EDSS scores were positively correlated with total fatigue and all its subdomains; the number of relapses was positively correlated with cognitive fatigue; total fatigue and its subdomains were moderately and negatively correlated with all QOL dimensions. Conclusion: Disability status in NMO patients is associated with overall fatigue and its subdomains; relapse frequency is linked to cognitive fatigue; fatigue is negatively correlated with quality of life.
Keywords: China, Fatigue, Neuromyelitis Optica, Quality of Life, Nursing Care
Received: 11 Aug 2025; Accepted: 13 Nov 2025.
Copyright: © 2025 Miao and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiaohui Miao, hxmxh2015@163.com
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