ORIGINAL RESEARCH article
Front. Neurol.
Sec. Neurotechnology
This article is part of the Research TopicIntegrating Technology and Policy for Enhanced Neurological and Mental Health OutcomesView all articles
ASSESSMENT OF BRAIN Compliance IN PATIENTS WITH MIGRAINE: USE OF NON-INVASIVE INTRACRANIAL MONITORING IN OUTPATIENT CLINICS
Provisionally accepted
Luiz Severo Bem Junior1
Otávio da Cunha Ferreira Neto2*
Igor Antônio Pereira3
Marcelo Moraes Valença4Hildo Rocha Cirne de Azevedo Filho4- 1Hospital da Restauracao Governador Paulo Guerra, Recife, Brazil
- 2Universidade de Sao Paulo Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto, Ribeirao Preto, Brazil
- 3Universidade de Sao Paulo Faculdade de Medicina de Ribeirao Preto, Ribeirao Preto, Brazil
- 4Hospital das Clinicas da Universidade Federal de Pernambuco, Recife, Brazil
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This study aimed to characterize the morphology of the cerebral compliance monitoring curve in patients with primary headaches, specifically differentiating between migraine with aura and migraine without aura, using non-invasive intracranial monitoring. This study is innovative in that it applies Brain4Care® technology in an outpatient setting to differentiate migraine types, making a significant contribution to understanding the pathophysiology of headaches and thus improving clinical management strategies. A cross-sectional, prospective study was carried out with 50 patients seen at an outpatient clinic specializing in pain. Variables such as the P2/P1 ratio, time to peak (TTP), and the morphology of the cerebral compliance wave were assessed, as well as demographic and clinical factors. A high prevalence of altered P2/P1 ratio (P2 > P1) was observed in patients suffering from migraine with aura. Statistical analyses indicated significant associations between this ratio and factors such as age and the presence of symptoms at the time of the examination. The findings emphasize the importance of the P2/P1 ratio and TTP as indicators for differentiating primary headaches. A non-invasive intracranial monitoring offers valuable insights into brain dynamics, enabling more accurate diagnoses and personalized interventions in outpatient settings. Brain4Care® technology is emerging as a promising tool for the non-invasive monitoring of cerebral compliance, with the potential to revolutionize clinical management of migraines. Future studies should extend the validation of these findings and explore new applications for this technology in clinical practices.
Keywords: Brain compliance, Migraine, outpatient clinic, Non-invasive intracranial monitoring, Brain4Care®
Received: 13 Aug 2025; Accepted: 30 Oct 2025.
Copyright: © 2025 Junior, Ferreira Neto, Pereira, Valença and Filho. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Otávio da Cunha Ferreira Neto, otaviocferreiraneto@gmail.com
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