ORIGINAL RESEARCH article
Front. Neurol.
Sec. Stroke
This article is part of the Research TopicNew horizons in stroke management: Volume IIView all 6 articles
Association Between Systemic Immune-Inflammation Index at Admission and Post-Stroke Depression in Patients With Acute Ischemic Stroke
Provisionally accepted
- The Affiliated Hospital of Qingdao University, Qingdao, China
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Background: Post-stroke depression (PSD) is one of the most common neuropsychiatric complications among stroke survivors, with a substantial impact on functional recovery and quality of life. This study aimed to investigate the association between the systemic immune-inflammation index (SII) at admission and the occurrence of PSD in patients with acute ischemic stroke (AIS). Methods: We prospectively enrolled 318 consecutive patients with first-ever AIS admitted to our hospital between August 2024 and March 2025. Venous blood samples were collected at admission, and SII was calculated as neutrophil count×platelet count/lymphocyte count. At 3 months post-stroke, depressive symptoms were assessed using the 17-item Hamilton Depression Rating Scale (HAMD-17). Patients with a HAMD-17 score >7 were diagnosed with PSD and categorized accordingly into PSD and non-PSD groups. Results: At the 3-month follow-up, 98 patients (30.82%) were diagnosed with PSD. Compared with the non-PSD group, patients in the PSD group had significantly higher SII values [658.66 (468.73-958.90) vs. 476.71 (362.73-646.83), P < 0.001]. In multivariate logistic regression analysis, after adjusting for potential confounders, patients in the highest SII tertile had a significantly increased risk of developing PSD compared with those in the lowest tertile (OR = 3.502, 95% CI: 1.582-7.752, P = 0.002). Receiver operating This is a provisional file, not the final typeset article characteristic (ROC) curve analysis identified an optimal SII cutoff value of 602.503 for predicting PSD, with a sensitivity of 0.582, a specificity of 0.700, and an area under the curve (AUC) of 0.659 (95% CI: 0.592–0.726, P < 0.001). Conclusions: Elevated SII levels at admission are positively associated with the development of PSD in AIS patients, suggesting that SII may serve as a valuable inflammatory biomarker for early identification of patients at high risk for PSD.
Keywords: Acute ischemic stroke, post-stroke depression, systemic immune-inflammation index, First-ever, biomarker
Received: 15 Aug 2025; Accepted: 27 Nov 2025.
Copyright: © 2025 SU, Chi, You, Zhao, Wang, ZHOU and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xin Li
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