ORIGINAL RESEARCH article
Front. Neurol.
Sec. Headache and Neurogenic Pain
Navigating Migraine Chronicity: The Role of Environmental Risk Factors and Triggers
Provisionally accepted
Hasan Doğan1*
Bilge Piri Cinar1
Osman Iyilikci2
Ezgi Uluduz3Sevim Eyüpoglu4Mustafa Iskender5Ummugulsum Kadioglu1
Derya Uluduz6
Aynur Özge7- 1Samsun Universitesi Tip Fakultesi, Canik, Türkiye
- 2Manisa Celal Bayar Universitesi, Manisa, Türkiye
- 3Koc Universitesi Tip Fakultesi, Istanbul, Türkiye
- 4Brain 360 Holistic Aproach Center, İstanbul, Türkiye
- 5Private Practice, Kocaeli, Türkiye
- 6Istanbul Universitesi Istanbul Tip Fakultesi, Istanbul, Türkiye
- 7Mersin Universitesi Tip Fakultesi, Mersin, Türkiye
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Purpose: Migraine is a prevalent and debilitating neurological condition that can significantly impact a person's quality of life. While various genetic and environmental factors contribute to the development and chronification of migraine, the role of specific environmental factors in the chronification of this condition remains inadequately explored. This article aims to address this research gap by focusing on the impact of manageable and unmanageable factors on the chronicity of migraine. Patients and methods: This cross-sectional observational study included 498 patients diagnosed with episodic or chronic migraine. Demographic characteristics of the patients were recorded on the demographic data form. Then, the patient's headache characteristics (duration, type, presence of aura, accompanying features, etc.) and the answers to the questions about possible triggers of migraine and environmental factors were recorded in the data form. Results: In chronic migraine group reported oversleeping, stress as a trigger at a higher rate versus episodic migraine group. In the episodic migraine group, it was found that participants who have TV transmitters were significantly less likely to benefit from treatment, while in chronic migraine group, it was found that participants who have pets were significantly less likely to benefit from treatment. Conclusion: In conclusion, this study sheds light on the intricate relationship between environmental factors, migraine phenotype, and treatment response. By employing comprehensive statistical methods and analyzing a rich dataset, we have gained valuable insights into the complexities of migraine management.
Keywords: chronic migraine, environmental factors, episodic migraine, Treatment, Migraine
Received: 19 Aug 2025; Accepted: 10 Nov 2025.
Copyright: © 2025 Doğan, Piri Cinar, Iyilikci, Uluduz, Eyüpoglu, Iskender, Kadioglu, Uluduz and Özge. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hasan Doğan, dr.hasandogan@outlook.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.