ORIGINAL RESEARCH article
Front. Neurol.
Sec. Movement Disorders
Videonystagmography features and clinical symptoms correlate with Parkinson's clinical subtypes
Provisionally accepted
- The First Affiliated Hospital of Hainan Medical University, Haikou, China
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Objective To analyse video nystagmography (VNG) characteristics in patients with different motor subtypes of Parkinson's disease (PD) and evaluate the correlation between VNG parameters and non-motor symptom severity, thereby advancing the understanding of PD heterogeneity. Methods Sixty-nine PD patients diagnosed at the First Affiliated Hospital of Hainan Medical College from December 2022 to January 2024 were enrolled, including 35 in the Tremor Dominant (TD) group and 34 in the Postural Instability/Gait Difficulty (PIGD) group, with 38 healthy controls (HC). Motor and non-motor symptoms were assessed, and VNG was performed to record eye-movement abnormalities. Clinical data and VNG parameters were compared among groups, and correlation analyses were conducted in TD and PIGD groups. Results Vertical saccadic latency and smooth pursuit vertical gain significantly differed among three groups (P<0.05). H-Y stage (P=0.013), MDS-UPDRS III (P=0.010), HAMA (P=0.024), and HAMD (P=0.021) were significantly different between TD and PIGD, while MDS-UPDRS I/II, MMSE and MoCA showed no significant differences (all P>0.05). In PIGD patients, VNG parameters were negatively correlated with MDS-UPDRS III and H-Y stage and positively correlated with HAMD (P<0.05). In TD patients, VNG parameters were negatively correlated with HAMA and HAMD (P<0.05). Conclusion VNG indices differed among PD motor subtypes and were associated with non-motor symptoms, indicating VNG may provide supportive clinical evidence for understanding PD subtype-related functional differences.
Keywords: Parkinson's disease, Videonystagmography, Motor symptoms, non-motor symptoms, Correlation analysis
Received: 27 Aug 2025; Accepted: 03 Nov 2025.
Copyright: © 2025 Zheng, Xie, Ma, Chen, Wang and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ye Xu, xuye19871987@outlook.com
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