Prevalence of Cannabis Use Disorders and Associated Factors Among Privately Insured Adults with Epilepsy

Katarzyna Czerniak^1*Youngran Kim²Refugio Sepulveda³Sahiti Myneni⁴Robert Addy¹Ross Shegog¹

• ¹The University of Texas Health Science Center at Houston Center for Health Promotion and Prevention Research, Houston, United States
• ²The University of Texas Health Science Center at Houston Center for Health Care Data, Houston, United States
• ³University of Arizona Med and Enid Zuckerman College of Public Health, Tucson, United States
• ⁴The University of Texas Health Science Center at Houston D. Bradley McWilliams School of Biomedical Informatics, Houston, United States

ABSTRACT Background: As cannabis is increasingly used as a treatment option for epilepsy, people with epilepsy (PWE) may be at higher risk of developing cannabis use disorder (CUD). This study aimed to estimate the prevalence of CUD among privately insured PWE in the United States using IQVIA's 2022 PharMetrics® Plus for Academics health plan claims database. Methods: A cross-sectional analysis was conducted using 2022 IQVIA PharMetrics® Plus for Academics health plan claims data containing longitudinal view of inpatient and outpatient services, prescription and office/outpatient administered drugs, costs and detailed enrollment information. Individuals with epilepsy aged 18 years and older were included. ICD-10-CM codes were used to identify epilepsy, CUD, and comorbidity conditions including mood disorders, anxiety, tobacco use, alcohol use, migraines, and sleep apnea. The prevalence of CUD was estimated, and associations between CUD and potential predictors were examined using multivariable modified Poisson regression to calculate adjusted risk ratios (aRRs). Results: The prevalence of CUDs among U.S. PWE was 1.1% based on 2022 data from an analytic sample of 63,713 unique enrollees. PWE were on average 54.3±17.2 years old and 53.6% were female. PWE with CUD were more likely to be young adult males and those 18-34 years old. PWE with CUD had six times more tobacco use and three times more mood disorders than those without CUD. PWE 18 to 24 years old were associated with a more than five times higher risk for CUD compared to PWE who were 65+ (aRR: 5.04, 95% CI: 3.83 – 6.65, P-value: <.001). Tabacco and alcohol use were associated with 6-fold increase (aRR: 5.8, 95% CI: 4.89 – 7.06, P-value: <.000) and 3-fold increase (aRR: 2.83, 95% CI: 2.21 – 3.64, P-value:<.001) respectively. Conclusion: PWE with substance use and psychiatric disorders are more likely to have CUD. Given the widespread prevalence of marijuana legalization across the U.S., increased awareness and potential screening for substance use disorders needs to be considered in epilepsy clinics.