Your new experience awaits. Try the new design now and help us make it even better

ORIGINAL RESEARCH article

Front. Neurol.

Sec. Neuromuscular Disorders and Peripheral Neuropathies

Volume 16 - 2025 | doi: 10.3389/fneur.2025.1696583

Anti-ALDOA antibody: a novel diagnostic-associated autoantibody in myasthenia gravis

Provisionally accepted
Mengdi ZhangMengdi Zhang1,2Yingna ZhangYingna Zhang1,2Peipei LiuPeipei Liu1,2Qingye GaoQingye Gao1,2Qian LiuQian Liu1,2Xinyue ZhouXinyue Zhou1,2Ruichen LiuRuichen Liu1,2Xue ZhaoXue Zhao1,2Jing ZhangJing Zhang1,2Jia HuJia Hu1,2Haiyan DongHaiyan Dong1,2Jing LiuJing Liu1,2Junhong YangJunhong Yang3Zhe RuanZhe Ruan4Ting ChangTing Chang4*Jie LvJie Lv1,2*Feng GaoFeng Gao1,2*
  • 1Zhengzhou University, Zhengzhou, China
  • 2Department of Neuroimmunology, Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China
  • 3The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China
  • 4Air Force Medical University Tangdu Hospital, Xi'an, China

The final, formatted version of the article will be published soon.

Select one of your emails

You have multiple emails registered with Frontiers:

Notify me on publication

Please enter your email address:

If you already have an account, please login

You don't have a Frontiers account ? You can register here

In the present study, we report a novel autoantibody in patients with myasthenia gravis. TBA results showed autoantibodies targeting muscle proteins exist in the serum of the seronegative myasthenia gravis patients. ALDOA was identified as the target antigen by immunoprecipitation, mass spectrometry and Western blot. The transfected cells were used to react with the serum antibodies of MG patients. The autoantibodies may be a new biomarker for the diagnosis of MG.

Keywords: Seronegative myasthenia gravis, clinical diagnosis, Autoantibody, Tissue based assay, Proteomics

Received: 01 Sep 2025; Accepted: 03 Oct 2025.

Copyright: © 2025 Zhang, Zhang, Liu, Gao, Liu, Zhou, Liu, Zhao, Zhang, Hu, Dong, Liu, Yang, Ruan, Chang, Lv and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Ting Chang, changting1981@163.com
Jie Lv, ljq19972006@126.com
Feng Gao, gaoyuanshan@126.com

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material