SYSTEMATIC REVIEW article
Front. Neurol.
Sec. Stroke
Ischemic Stroke Associated with Adenomyosis-Related Abnormal Uterine Bleeding: A Systematic Review of Management and Outcomes
Provisionally accepted
- 1Department of Obstetrics and Gynecology in Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province, Hangzhou, China
- 2Department of Obstetrics and Gynaecology, People's Hospital of Putuo District., zhoushan, China
- 3Department of Neurology, Hangzhou Hospital of Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University,, Hangzhou, China
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Background: Adenomyosis is frequently associated with abnormal uterine bleeding (AUB) and anemia. In the setting of arterial stenosis or hypercoagulability, AUB may precipitate ischemic stroke. However, the optimal management strategy remains unclear. Methods: In accordance with PRISMA 2020, we systematically searched PubMed, Web of Science, CNKI, and Wanfang from inception to November 20, 2024, without language restrictions. Eligible studies were human case reports or case series that described adenomyosis-associated ischemic stroke with extractable data on management and outcomes. Data extraction was performed independently by two reviewers, and risk of bias was assessed using the JBI tool. A descriptive synthesis was conducted, and Fisher's exact tests were applied where appropriate. Results: Eighteen studies involving 24 patients fulfilled the inclusion criteria. Among these patients, 66.7% experienced stroke onset during menstruation, 85.7% presented with anemia, and more than 95% showed elevated CA125 and D-dimer levels. Stroke recurrence occurred in 55.6% of patients who received conservative management, compared with 0% of those who underwent hysterectomy (Fisher's exact p ≈ 0.005). In menstruation-related cases managed conservatively, the recurrence rate reached 83.3%. Conclusions: Current evidence indicates that rapid uterine hemostasis may facilitate timely initiation of antithrombotic therapy and thereby reduce recurrence risk in adenomyosis-associated stroke. Surgical management, particularly hysterectomy, appears more effective than conservative therapy in carefully selected high-risk patients. Larger prospective studies are needed to confirm these findings and to refine management strategies.
Keywords: Adenomyosis, Abnormal uterine bleeding, Cerebral Infarction, conservative treatment, Operation treatment
Received: 03 Sep 2025; Accepted: 19 Nov 2025.
Copyright: © 2025 Zheng, Zhang, Fang and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jianhua Yang, yjh2006@zju.edu.cn
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