Developing a machine learning model to assist in predicting treatment success in children with drug-resistant epilepsy

Achmad Rafli^1*Wisnu Ananta²Setyo Handryastuti¹Irawan Mangunatmadja¹Rahmad Mulyadi¹Aria Kekalih¹Anggi Gayatri¹Elisabeth Herini³

• ¹Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
• ²IPB University, Bogor, Indonesia
• ³Universitas Gadjah Mada Fakultas Kedokteran Kesehatan Masyarakat dan Keperawatan, Yogyakarta, Indonesia

Currently, the successfulness of reducing seizures through the selection of appropriate antiepileptic drugs (AED) in children with drug-resistant epilepsy remains a challenge due to variability characteristic in patients. This study aims to develop and evaluate machine learning models to treatment success in pediatric patients with drug-resistant epilepsy. This study will be conducted with an ambispective cohort. A total of 215 subjects will be taken from patients in Cipto Mangunkusumo Referral Hospital and Harapan Kita General Hospital. Supporting examinations will be also performed such as electroencephalography (EEG) and modified HARNESS Magnetic Resonance Imaging (MRI). The collected data will be analyzed by machine learning with several algorithms including support vector machine (SVM), decision tree (DT), random forest (RF), gradient boosting (GB), and their performance will be compared to determine the best model. This is the first study to utilize machine learning by integrating clinical data, EEG, MRI, and medication history to predict treatment success in pediatric patients with drug-resistant epilepsy in Indonesia. The developed model is expected to serve as a clinical decision supporting tool for pediatric neurologists to predict seizure control in children with DRE and determine appropriate therapeutic adjustments with more aggressively when uncontrolled seizures are predicted.