ORIGINAL RESEARCH article
Front. Neurol.
Sec. Pediatric Neurology
Urodynamic evaluation of neurogenic lower urinary tract dysfunction in children with Guillain-Barre syndrome within 6 months
Provisionally accepted
- 1Sichuan University West China Second University Hospital, Chengdu, China
- 2Sichuan provincial children's hospital, Meishan, China
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Abstract Objective This study aimed to evaluate urodynamic characteristics, identify high-risk and unfavorable urodynamic findings in children with neurogenic lower urinary tract dysfunction (NLUTD) secondary to Guillain-Barre syndrome (GBS) within 6 months since the onset of illness. Methods This study conducted a retrospective observational analysis of 16 children diagnosed with GBS complicated by NLUTD. Clinical data collected included demographic information, lower urinary tract symptoms, uroflowmetry results, post-void residual urine (PVRU), and urodynamic parameters. Follow-up assessments focused on high-risk urodynamic features-such as high detrusor pressure during the filling phase and low bladder compliance-as well as unfavorable findings, including detrusor overactivity, detrusor underactivity, or an acontractile bladder. Results The majority of patients presented with clinical symptoms of urinary retention. characterized by a decreased Qmax on uroflowmetry and elevated PVRU. Urodynamic study (UDS) revealed two predominant findings: reduced bladder sensation during the filling phase and detrusor underactivity during the voiding phase. At the 8-week follow-up, low bladder compliance and detrusor overactivity were observed in only 2 of the 16 patients (12.5%). During the filling phase, none of the patients exhibited high detrusor pressure (>40cmH₂O), while all cases demonstrated underactive bladder function during the voiding phase. By the 24-week follow-up, 12 patients (12/16, 75.0%) had achieved normal bladder compliance, with only one case persisting with low bladder compliance and detrusor overactivity. Additionally, 10 patients (10/16, 62.5%) who had presented with an underactive bladder during the voiding phase showed recovery by the 24-week assessment. 3 Conclusions The prognosis of autonomic dysfunction involving the urinary system in pediatric GBS was generally favorable, with most cases of GBS-associated NLUTS showing substantial reversibility, as confirmed by the normalization of urodynamic parameters over time.
Keywords: Guillain-Barre Syndrome, Neurogenic urinary bladder, Urinary Retention, Urodynamics, Children
Received: 16 Sep 2025; Accepted: 27 Nov 2025.
Copyright: © 2025 Long, Zhang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hui Zhang
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