MINI REVIEW article
Front. Neurol.
Sec. Neurorehabilitation
This article is part of the Research TopicTransforming Neurological Recovery: The Promise of Regenerative NeurorehabilitationView all 7 articles
Cellular Therapy in Neuromyelitis Optica Spectrum Disorder
Provisionally accepted
Kang Zhong
Yulan Tang*- First Affiliated Hospital, Guangxi Medical University, Nanning, China
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Abstract Neuromyelitis optica spectrum disorder (NMOSD) is a debilitating neuroimmune condition characterized by recurrent inflammatory episodes that result in progressive disability, substantial psychological distress, and significant economic burdens. While current immunosuppressive therapies reduce relapse rates, they fail to achieve a definitive cure. Cellular therapy has emerged as a novel therapeutic strategy, offering potential disease modification through immune cell modulation and immune system reorganization via in vivo transplantation of adult stem cells or genetically engineered somatic cells. This review synthesizes recent advancements in cellular therapy for NMOSD, aiming to improve understanding of it in NMOSD disease and provide a roadmap for future research.
Keywords: Neuromyelitis optica spectrum disease (NMOSD), Autologous hematopoietic stem cells(AHSC), Chimeric antigen receptor T cells (CAR-T), bone marrow-derived mesenchymal stem cells (BM-MSCs), Human umbilical cord-derived mesenchymal stem cells (HUC-MSCs)
Received: 24 Sep 2025; Accepted: 29 Oct 2025.
Copyright: © 2025 Zhong and Tang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yulan Tang, tangyulan7@163.com
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