ORIGINAL RESEARCH article
Front. Neurol.
Sec. Neuro-Oncology and Neurosurgical Oncology
Neuroendoscopic Resection of Pineal Region Tumors via the Transfrontal-Transventricular-Transforaminal Approach
Provisionally accepted
- Lanzhou University Second Hospital, Lanzhou, China
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Purpose: To evaluate the clinical efficacy of neuroendoscopic resection of pineal region tumors via the transfrontal-transventricular-transforaminal approach. Methods: Clinical data of eight patients with pineal region tumors who underwent this surgical approach at our institution between January 2020 and July 2025 were retrospectively reviewed. Results: The cohort consisted of seven males and one female, aged 3–52 years. Gross total resection (GTR) was achieved in three patients, near-total resection (NTR) in two, and subtotal resection (STR) in three. Three patients underwent combined radiotherapy and chemotherapy. Histopathological diagnoses included three mixed germ cell tumor, two low-grade glioma, one high-grade glioma, and one mature teratoma. Two patients developed subjective memory decline. During a follow-up period of 3 to 29 months, seven patients resumed normal daily activities, except for one who discontinued treatment due to tumor recurrence. Conclusion: Neuroendoscopic resection of pineal region tumors via the transfrontal-transventricular-transforaminal approach is a safe and effective technique, particularly for lesions extending into the third ventricle.
Keywords: Foramen of monro, Neuroendoscopy, Pineal region tumor, Transventricular approach, tumor resection
Received: 21 Sep 2025; Accepted: 03 Nov 2025.
Copyright: © 2025 Tengyun, Hou, Dong, Yang, Guo and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qiang Li, g1133677@163.com
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