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ORIGINAL RESEARCH article

Front. Neurol.

Sec. Neurorehabilitation

This article is part of the Research TopicThe Regeneration and Intervention of Neurological Tissue after Acute and Chronic Injuries: from Benchside to BedsideView all 7 articles

Comparison of Unilateral Biportal Endoscopic Lumbar Fusion and Modified Minimally Invasive Tubular Lumbar Fusion for Lumbar Disc Herniation: A Two-Year Retrospective Study

Provisionally accepted
Jialong  QiJialong Qi1,2*Mingxiang  LiuMingxiang Liu1,2Tao  ShanTao Shan1,2Zhou  DongZhou Dong1,2Guosong  HanGuosong Han1,2Zhihao  NiZhihao Ni1,2Ke  ZhengKe Zheng1Li  MaLi Ma1Zhidong  ZhangZhidong Zhang1
  • 1Third Affiliated Hospital of Anhui Medical University, Hefei, China
  • 2Anhui Medical University, Hefei, China

The final, formatted version of the article will be published soon.

Objective: To compare the medium-and long-term clinical outcomes of Unilateral Biportal Endoscopic Lumbar Fusion (UBE-TLIF) and Modified Minimally Invasive Tubular Lumbar Fusion (MIS-TLIF) for treating Lumbar Disc Herniation (LDH). Methods: A retrospective analysis was conducted on 86 patients with single-level LDH who underwent surgery between August 2022 and August 2023. Patients were allocated to two groups: 42 underwent UBE-TLIF and 44 underwent MIS-TLIF. We recorded operative time, postoperative drainage volume, and complication rates. Pain and functional recovery were assessed using the Visual Analogue Scale (VAS) for back and leg pain and the Oswestry Disability Index (ODI) preoperatively and at 3 days, 1, 6, 12, and 24 months postoperatively. Surgical outcomes were evaluated at 12 months using the Macnab criteria. Results: The mean operative time was significantly longer in the UBE-TLIF group than in the MIS-TLIF group (140.42 ± 16.02 min vs. 92.15 ± 13.14 min, P < 0.05). However, the UBE-TLIF group had a significantly lower postoperative drainage volume (65.79 ± 13.46 ml vs. 103.58 ± 12.56 ml, P < 0.05). Both groups showed significant improvements in VAS and ODI scores at all postoperative time points compared to preoperative baselines (P < 0.05). Although most intergroup differences in VAS and ODI scores were not statistically significant (P > 0.05), the UBE-TLIF group demonstrated lower scores across all follow-ups, with the difference at 3 days postoperatively being significant (P < 0.05). According to the Macnab criteria, the excellent-good rate was 95.2% for UBE-TLIF and 95.5% for MIS-TLIF, indicating no significant difference (P > 0.05). The fusion rates, assessed via the Bridwell grading system, were 90.4% (UBE-TLIF) and 93.2% (MIS-TLIF), which was also not a statistically significant difference (P > 0.05). Conclusion: Both UBE-TLIF and MIS-TLIF demonstrate comparable medium-and long-term clinical efficacy for LDH. UBE-TLIF is associated with less postoperative drainage and significantly better early pain relief, suggesting less soft tissue trauma. However, it was linked to a longer operative time in this study.

Keywords: Lumbar disc herniation, MIS-TLIF, Modified Minimally Invasive Tubular Lumbar Fusion, UBE-TLIF, Unilateral Biportal Endoscopic Lumbar Fusion

Received: 21 Oct 2025; Accepted: 28 Nov 2025.

Copyright: © 2025 Qi, Liu, Shan, Dong, Han, Ni, Zheng, Ma and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Jialong Qi

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