SYSTEMATIC REVIEW article
Front. Neurol.
Sec. Epilepsy
This article is part of the Research TopicGenotype-Phenotype Correlations, Genetic Mechanisms of Phenotypic Heterogeneity, Optimized Diagnosis and Targeted Therapies in Epilepsy and Neurodevelopmental DisordersView all 4 articles
Exploring the Landscape of Developmental and Epileptic Encephalopathies and Gene Research Global Dynamics via Bibliometric Study 2001–2025
Provisionally accepted
- First Affiliated Hospital of Jinan University, Guangzhou, China
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Objective (Background): The aim of this study is to analyze the current research status and future prospects of the field of developmental and epileptic encephalopathy (DEE) and gene through bibliometric methods. It aims to explore the trends and potential developments in this field. Methods: A systematic search of the DEE and gene literature from 2001 to 2025.2 was conducted using the Web of Science core collection database. Supplementary PubMed searches for this field's clinical research trends ensured verified data comprehensiveness and methodological rigor. Quantitative analysis of co-authorship networks was performed using VOSviewer and CiteSpace tools. Results: A total of 1022 articles related to the field of DEE and gene were included in this study, authored by 8355 researchers affiliated with 7238 institutions across 315 countries. USA emerged as the leading research countries in this field, with the National Institute of Health and Medical Research. Professor Ingrid Scheffer had the highest number of publications in this field, and the journal Epilepsy had the highest citation count. The research hotspots in this field revolved around epilepsy, mutations, epileptic encephalopathy, de novo mutations, and seizure. Conclusion: The research on DEE and gene is currently experiencing rapid growth. The field is expanding, and the research is becoming more in-depth.
Keywords: Developmental and epileptic encephalopathies, gene, bibliometric analysis, Web of Science, VOSviewer, Citespace
Received: 27 Oct 2025; Accepted: 26 Nov 2025.
Copyright: © 2025 Liu, Zhang, Ding, Zhao and Meng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ying Zhao
Heng Meng
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