Frontiers in Stroke | Mechanisms, Models, and Biomarkers of Stroke

Study Protocol

Accepted on 04 Jan 2026

Comprehensive Immunological Profiling in Acute Ischemic Stroke: Myeloid Cell Activation and Molecular Signatures in Blood and Thrombus during Mechanical Thrombectomy

in Mechanisms, Models, and Biomarkers of Stroke

Wirginia Krzyściak
Tadeusz Popiela

Frontiers in Stroke

Original Research

Published on 20 Nov 2025

Plasma apolipoprotein E and monocyte chemoattractant protein-1 levels in young people with HIV and ischemic stroke in Lusaka, Zambia

in Mechanisms, Models, and Biomarkers of Stroke

Stanley Zimba
Owen Ngalamika
Emmanuel Mukambo
Mike Chisha
Violet Kayamba
Lloyd Mulenga
Omar Siddiqi
Deanna Saylor
Owen A. Ross
Masharip Atadzhanov

Frontiers in Stroke

doi 10.3389/fstro.2025.1595809

476 views

Original Research

Published on 22 Jul 2025

Association between ischemic stroke and hyperintense plaques detected by high-resolution vessel wall MRI in Japanese patients with intracranial atherosclerotic disease

in Mechanisms, Models, and Biomarkers of Stroke

Naoki Takayama
Takakuni Maki
Yasutaka Fushimi
Masakazu Okawa
Yohei Mineharu
Kiyofumi Yamada
Tao Yang
Yu Yamamoto
Keita Suzuki
Ken Yasuda

Frontiers in Stroke

doi 10.3389/fstro.2025.1610666

1,201 views

Editorial

Published on 11 Jul 2025

Editorial: Post-stroke cognitive decline and dementia: unraveling mechanisms, models, and biomarkers

in Mechanisms, Models, and Biomarkers of Stroke

Robert T. Mallet
Rebecca F. Gottesman
Paco S. Herson

Frontiers in Stroke

doi 10.3389/fstro.2025.1646796

1,574 views

Mini Review

Published on 09 May 2025

Models and mechanisms of post-stroke dementia and cognitive impairment

in Mechanisms, Models, and Biomarkers of Stroke

Romeesa Khan
Patrick Devlin
Akihiko Urayama
Rodney M. Ritzel

Frontiers in Stroke

doi 10.3389/fstro.2025.1563924

4,762 views
1 citation

Review

Published on 07 Jan 2025

Linking evidence for targeted blood biomarkers in post-stroke cognitive impairment and dementia

in Mechanisms, Models, and Biomarkers of Stroke

Jinny Hong
Katherine Mun
Kyle C. Kern
Marissa Thirion
Jason D. Hinman

Frontiers in Stroke

doi 10.3389/fstro.2024.1491542

2,857 views

Original Research

Published on 04 Dec 2024

Blood-brain barrier disruption mediates the association between cerebral small vessel disease and clinical outcome after stroke: a secondary analysis of the Lesion Evolution in Stroke and Ischemia on Neuroimaging study

in Mechanisms, Models, and Biomarkers of Stroke

Derrick N. Okine
Kyle C. Kern
Marie Luby
Lawrence L. Latour
Rebecca F. Gottesman

Frontiers in Stroke

doi 10.3389/fstro.2024.1510359

1,735 views

Original Research

Published on 26 Nov 2024

High wall shear stress-dependent podosome formation in a novel murine model of intracranial aneurysm

in Mechanisms, Models, and Biomarkers of Stroke

Jiayi Lu
Mengjun Dai
Yuanqing Yan
Louise D. McCullough
Yan-Ning Rui
Zhen Xu

Frontiers in Stroke

doi 10.3389/fstro.2024.1494559

1,769 views
2 citations

Case Report

Published on 18 Nov 2024

Case report: Cervical arterial dissections in the setting of recent COVID-19 infection

in Mechanisms, Models, and Biomarkers of Stroke

Sanghee Lim
Matthew M. Rode
Zafer Keser
Kelly D. Flemming

Frontiers in Stroke

doi 10.3389/fstro.2024.1366947

2,152 views

Original Research

Published on 29 Oct 2024

Brain volume is a better biomarker of outcomes in ischemic stroke compared to brain atrophy

in Mechanisms, Models, and Biomarkers of Stroke

Kenda Alhadid
Robert W. Regenhardt
Natalia S. Rost
Markus D. Schirmer

Frontiers in Stroke

doi 10.3389/fstro.2024.1468772

1,598 views
4 citations

Original Research

Published on 14 Aug 2024

Astroglial CD38 impairs hippocampal synaptic plasticity after global cerebral ischemia

in Mechanisms, Models, and Biomarkers of Stroke

Amelia M. Burch
Ami Haas
James E. Orfila
Erika Tiemeier
Cassidy De Anda Gamboa
Nicholas Chalmers
Nidia Quillinan
Paco S. Herson

Frontiers in Stroke

doi 10.3389/fstro.2024.1423887

2,289 views

Review

Published on 14 Jun 2024

The NLRP3 inflammasome in ischemic stroke

in Mechanisms, Models, and Biomarkers of Stroke

Sepiso K. Masenga
Annet Kirabo

Frontiers in Stroke

doi 10.3389/fstro.2024.1382379

3,990 views
5 citations

Case Report

Published on 03 Apr 2024

Case report: Three characteristics of tyrosine kinase inhibitor-associated cerebrovascular stenosis. High threshold for infarction, atypical infarct area, and vascular recoverability under the use of ponatinib

in Mechanisms, Models, and Biomarkers of Stroke

Akira Hanazono
Masamichi Abe
Shuntaro Togashi
Teruko Takahashi
Naoto Takahashi
Masashiro Sugawara

Frontiers in Stroke

doi 10.3389/fstro.2024.1367869

1,892 views

Original Research

Published on 19 Mar 2024

Subarachnoid hemorrhage-associated brain injury and neurobehavioral deficits are reversed with synthetic adropin treatment through sustained Ser1179 phosphorylation of endothelial nitric oxide synthase

in Mechanisms, Models, and Biomarkers of Stroke

William S. Dodd
Devan Patel
Dimitri Laurent
Brandon Lucke-Wold
Koji Hosaka
Richard D. Johnson
Nohra Chalouhi
Andrew A. Butler
Eduardo Candelario-Jalil
Brian L. Hoh

Frontiers in Stroke

doi 10.3389/fstro.2024.1371140

4,082 views
4 citations

Editorial

Published on 07 Nov 2023

Editorial: Intracranial pressure regulation in stroke

in Mechanisms, Models, and Biomarkers of Stroke

Daniel J. Beard
Lucy A. Murtha
Damian D. McLeod

Frontiers in Stroke

doi 10.3389/fstro.2023.1323696

1,580 views

Mini Review

Published on 23 Oct 2023

Inflammation—The new treatment target for ischaemic stroke prevention

in Mechanisms, Models, and Biomarkers of Stroke

Sarah Gorey
John J. McCabe
Peter J. Kelly

Frontiers in Stroke

doi 10.3389/fstro.2023.1241506

3,043 views
2 citations

Mini Review

Published on 07 Sep 2023

Potential and limitations of computed tomography images as predictors of the outcome of ischemic stroke events: a review

in Mechanisms, Models, and Biomarkers of Stroke

Gonçalo Oliveira
Ana Catarina Fonseca
José M. Ferro
Arlindo L. Oliveira

Frontiers in Stroke

doi 10.3389/fstro.2023.1242901

2,780 views
1 citation

Brief Research Report

Published on 19 Jul 2023

NLRP3 inflammasome inhibition protects against intracranial aneurysm rupture and alters the phenotype of infiltrating macrophages

in Mechanisms, Models, and Biomarkers of Stroke

William S. Dodd
Devan Patel
Kartik Motwani
Brandon Lucke-Wold
Koji Hosaka
Brian L. Hoh

Frontiers in Stroke

doi 10.3389/fstro.2023.1202137

1,323 views

Mini Review

Published on 29 Jun 2023

Animal models of focal ischemic stroke: brain size matters

in Mechanisms, Models, and Biomarkers of Stroke

Blazej Nowak
Piotr Rogujski
Raphael Guzman
Piotr Walczak
Anna Andrzejewska
Miroslaw Janowski

Frontiers in Stroke

doi 10.3389/fstro.2023.1165231

6,128 views
3 citations

Review

Published on 29 Mar 2023

Relationship between edema and intracranial pressure following intracerebral hemorrhage in rat

in Mechanisms, Models, and Biomarkers of Stroke

Anna C. J. Kalisvaart
Natasha A. Bahr
Frederick Colbourne

Frontiers in Stroke

doi 10.3389/fstro.2023.1155937

5,944 views
5 citations

Review

Published on 21 Feb 2023

Intracranial pressure elevation post-stroke: Mechanisms and consequences

in Mechanisms, Models, and Biomarkers of Stroke

Rebecca J. Hood
Daniel J. Beard
Damian D. McLeod
Lucy A. Murtha
Neil J. Spratt

Frontiers in Stroke

doi 10.3389/fstro.2023.1119120

15,174 views
10 citations

Mini Review

Published on 06 Feb 2023

Subarachnoid hemorrhage: New insights on pathogenesis

in Mechanisms, Models, and Biomarkers of Stroke

Divine C. Nwafor
Allison L. Brichacek
Michael S. Rallo
Nina Bidwai
Robert A. Marsh

Frontiers in Stroke

doi 10.3389/fstro.2023.1110506

7,162 views
4 citations

Mini Review

Published on 18 Jan 2023

Advances in PET imaging of ischemic stroke

in Mechanisms, Models, and Biomarkers of Stroke

Paulette D. Orhii
Muhammad E. Haque
Masahiro Fujita
Sudhakar Selvaraj

Frontiers in Stroke

doi 10.3389/fstro.2022.1093386

5,761 views
4 citations

Original Research

Published on 21 Dec 2022

Gut microbial dysbiosis correlates with stroke severity markers in aged rats

in Mechanisms, Models, and Biomarkers of Stroke

Tyler C. Hammond
Sarah Messmer
Jacqueline A. Frank
Doug Lukins
Rita Colwell
Ai-Ling Lin
Keith R. Pennypacker

Frontiers in Stroke

doi 10.3389/fstro.2022.1026066

4,168 views
9 citations

28 articles

articles

Comprehensive Immunological Profiling in Acute Ischemic Stroke: Myeloid Cell Activation and Molecular Signatures in Blood and Thrombus during Mechanical Thrombectomy

Plasma apolipoprotein E and monocyte chemoattractant protein-1 levels in young people with HIV and ischemic stroke in Lusaka, Zambia

Association between ischemic stroke and hyperintense plaques detected by high-resolution vessel wall MRI in Japanese patients with intracranial atherosclerotic disease

Editorial: Post-stroke cognitive decline and dementia: unraveling mechanisms, models, and biomarkers

Models and mechanisms of post-stroke dementia and cognitive impairment

Linking evidence for targeted blood biomarkers in post-stroke cognitive impairment and dementia

Blood-brain barrier disruption mediates the association between cerebral small vessel disease and clinical outcome after stroke: a secondary analysis of the Lesion Evolution in Stroke and Ischemia on Neuroimaging study

High wall shear stress-dependent podosome formation in a novel murine model of intracranial aneurysm

Case report: Cervical arterial dissections in the setting of recent COVID-19 infection

Brain volume is a better biomarker of outcomes in ischemic stroke compared to brain atrophy

Astroglial CD38 impairs hippocampal synaptic plasticity after global cerebral ischemia

The NLRP3 inflammasome in ischemic stroke

Case report: Three characteristics of tyrosine kinase inhibitor-associated cerebrovascular stenosis. High threshold for infarction, atypical infarct area, and vascular recoverability under the use of ponatinib

Subarachnoid hemorrhage-associated brain injury and neurobehavioral deficits are reversed with synthetic adropin treatment through sustained Ser1179 phosphorylation of endothelial nitric oxide synthase

Editorial: Intracranial pressure regulation in stroke

Inflammation—The new treatment target for ischaemic stroke prevention

Potential and limitations of computed tomography images as predictors of the outcome of ischemic stroke events: a review

NLRP3 inflammasome inhibition protects against intracranial aneurysm rupture and alters the phenotype of infiltrating macrophages

Animal models of focal ischemic stroke: brain size matters

Relationship between edema and intracranial pressure following intracerebral hemorrhage in rat

Intracranial pressure elevation post-stroke: Mechanisms and consequences

Subarachnoid hemorrhage: New insights on pathogenesis

Advances in PET imaging of ischemic stroke

Gut microbial dysbiosis correlates with stroke severity markers in aged rats