ORIGINAL RESEARCH article

Front. Surg.

Sec. Surgical Oncology

Volume 12 - 2025 | doi: 10.3389/fsurg.2025.1491498

Excellent Patient-Reported Long-Term Quality of Life After an Ivor Lewis Esophagectomy for Cancer

Provisionally accepted
Alisa N BlumenthalerAlisa N Blumenthaler1Cyrus A FeizpourCyrus A Feizpour1Shadia I JalalShadia I Jalal2Kevin J LopezKevin J Lopez1Neal K RamchandaniNeal K Ramchandani1Joshua McalisterJoshua Mcalister3Susan PerkinsSusan Perkins4Yan HanYan Han4Karen M RiegerKaren M Rieger5Joann BrooksJoann Brooks5Kenneth A KeslerKenneth A Kesler5*
  • 1Indiana University Melvin and Bren Simon Cancer Center, Department of Surgery, General Surgery Division, Indianapolis, United States
  • 2Indiana University Melvin and Bren Simon Cancer Center, Department of Medicine, Medical Oncology Division, Indianapolis, United States
  • 3Indiana University Melvin and Bren Simon Cancer Center, Department of Radiology, Indianapolis, United States
  • 4Indiana University Melvin and Bren Simon Cancer Center, Department of Biostatistics and Health Data Science, Indianapolis, United States
  • 5Indiana University Melvin and Bren Simon Cancer Center, Department of Surgery, Cardiothoracic Surgery Division, Indianapolis, United States

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Early satiety was the only item with >33% negative responses (n=30, 45%). FACT-E total scores were also favorable (median, IQR:146.0, 126.0-161.0; total possible:176.0). Delayed emptying, identified in 17 (27.4%) participants, was not associated with HRQOL scores.Patient-reported long-term HRQOL following a consistently performed esophagectomy technique was very favorable in all subscales, but symptoms of early satiety persisted. Delayed postoperative conduit emptying did not impact HRQOL. These results should be compared to other consistently performed esophagectomy techniques..

Keywords: esophageal surgery, esophageal cancer, Quality of Life, Long term survivors, Outcomes Assessment

Received: 05 Sep 2024; Accepted: 20 Jun 2025.

Copyright: © 2025 Blumenthaler, Feizpour, Jalal, Lopez, Ramchandani, Mcalister, Perkins, Han, Rieger, Brooks and Kesler. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Kenneth A Kesler, Indiana University Melvin and Bren Simon Cancer Center, Department of Surgery, Cardiothoracic Surgery Division, Indianapolis, United States

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material