REVIEW article
Front. Surg.
Sec. Reconstructive and Plastic Surgery
Volume 12 - 2025 | doi: 10.3389/fsurg.2025.1504563
This article is part of the Research Topic10th Anniversary of Frontiers in Surgery: Celebrating Progress and Envisioning the Future of Multidisciplinary SurgeryView all 11 articles
A REVIEW OF REGENERATIVE MEDICINE AND TISSUE ENGINEERING WITH A FOCUS ON WOUND HEALING AND ANTI-AGING
Provisionally accepted
- Brigham and Women's Hospital, Harvard Medical School, Boston, United States
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Regenerative medicine and tissue engineering explore the potential to enhance human healing, which is often limited by wound contraction, scarring, loss of function, and decreased quality of life. Biomaterials like synthetic scaffolds and implantable devices have been developed to circumvent the body's limited natural ability to heal, however, they may introduce their own complications such as toxic side effects. Advances in cell-based therapies, especially those involving embryonic stem cells (ESCs) and human-induced pluripotent stem cells (hiPSCs), offer an enhanced ability to regenerate, circumventing limitations of biomaterials and the body's limited ability to heal. There have been many recent advances in cell-therapies, both scaffold-based and scaffold-free products. Additionally, non-cell-based therapies are gaining traction in wound healing. These products, utilizing their ability to affect the principles of wound healing, have applications in anti-aging.Despite these advances, significant challenges remain. These technologies remain costly, may compromise ethical tenets, and may introduce safety risks. Future work should address these challenges. Refer to Figure 1 for a visual abstract.
Keywords: Tissue Engineering, Regenerative Medicine, Stem Cells, Aging, wound healing Font color: Black Hemostasis: vasoconstriction, fibrin-platelet clot formation Inflammation: neutrophil and macrophage recruitment, release of growth factors Proliferation: angiogenesis, Epithelialization
Received: 30 Sep 2024; Accepted: 16 May 2025.
Copyright: © 2025 Ganesan, Kiwanuka, Hamaguchi and Orgill. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Dennis Paul Orgill, Brigham and Women's Hospital, Harvard Medical School, Boston, United States
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