ORIGINAL RESEARCH article
Front. Surg.
Sec. Orthopedic Surgery
Volume 12 - 2025 | doi: 10.3389/fsurg.2025.1573679
This article is part of the Research TopicThe Role of Platelet Derivatives in Regenerative MedicineView all articles
Clinical outcomes of tibial nonunion treatment through the combination of PRP, autogenous iliac bone grafting, and augmentation plating
Provisionally accepted
- 1Eighth Clinical Medical College, Guangzhou University of Chinese Medicine, Foshan, Guangdong Province, China
- 2Foshan Hospital of Traditional Chinese Medicine, Foshan, Guangdong Province, China
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Objective To explore the clinical efficacy of PRP (Platelet-Rich Plasma), autogenous bone combined with augmentation plating in the treatment of tibial nonunion. Methods A total of 45 patients with tibial nonunion who fulfilled the inclusion criteria were meticulously selected and subsequently randomized into three distinct groups: Group A, which received PRP, autogenous bone grafting, and augmentation plating; Group B, which underwent autogenous bone grafting and augmentation plating; and Group C, which only received autogenous bone grafting. Each group comprised 15 patients. Detailed records were maintained for gender, age, BMI (Body Mass Index) as general information, surgery duration, blood loss, length of hospital stay, fracture healing time, and the Fernadez-Esteve score at three specific time points. Results No statistically significant differences were observed in the general demographic data, including gender, age, and BMI, among the three groups (P > 0.05). In terms of bone healing time, Group A exhibited the shortest duration, followed closely by Group B and then Group C. Additionally, Group A demonstrated significantly higher Fernadez-Esteve scores compared to Group B, with Group C trailing behind, at 3, 6, and 9 months postoperatively. Conclusion PRP, autogenous bone combined with augmentation plating in the treatment of tibial nonunion can promote fracture healing and repair, improve fracture healing rate, and the clinical effect is significant.
Keywords: Tibial nonunion, Platelet-Rich Plasma, Autologous bone graft, Augmentation plating, Fracture healing time
Received: 09 Feb 2025; Accepted: 20 Jun 2025.
Copyright: © 2025 Lu, Huo and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Enliang Chen, Eighth Clinical Medical College, Guangzhou University of Chinese Medicine, Foshan, Guangdong Province, China
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