ORIGINAL RESEARCH article
Front. Surg.
Sec. Colorectal and Proctological Surgery
Volume 12 - 2025 | doi: 10.3389/fsurg.2025.1581993
Circulating Cell-Free DNA and Tumor DNA dynamics in Obstructive Colon Cancer Undergoing Neoadjuvant Chemotherapy Following Stent Placement
Provisionally accepted- 1Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
- 2Department of General surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
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Background: To improve the prognosis of patients with obstructive colon cancer, performing neoadjuvant chemotherapy after self-expanding metallic stent (SEMS) placement followed by elective surgery is currently one of the treatment methods for obstructive colon cancer. However, the oncological risks of this treatment approach are currently unclear. To evaluate the oncological risks of this treatment model by detecting changes in circulating cell-free DNA (cfDNA) and circulating tumor DNA (ctDNA) during the stent placement combined with neoadjuvant chemotherapy process.Methods: From January to December 2023, 10 patients with obstructive colon cancer who received neoadjuvant chemotherapy after SEMS placement, followed by surgical treatment, were included in this study. Blood samples were collected one day before stent placement, three days after stent placement, one day before surgery, and one day after surgery. cfDNA and ctDNA in the blood were detected and analyzed.The stent placement success rate was 100%, with no cases of perforation, displacement, or reobstruction, and no perioperative deaths. After neoadjuvant chemotherapy, peripheral ctDNA decreased compared to before stent placement. There were no statistically significant differences in cfDNA and ctDNA changes at the four time points during the treatment process.Conclusions: This study did not find an increase in ctDNA after stent placement combined with chemotherapy, suggesting that the model of stent placement combined with neoadjuvant chemotherapy for obstructive colon cancer may be a safe and reliable therapy.
Keywords: circulating cell-free DNA, circulating tumor DNA, Obstructive colon cancer, self-expanding metallic stent (SEMS), Neoadjuvant chemotherapy
Received: 23 Feb 2025; Accepted: 01 Jul 2025.
Copyright: © 2025 Zhang, Han and Zhai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jiagang Han, Department of General surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China
Zhiwei Zhai, Department of General surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China
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