CASE REPORT article
Front. Surg.
Sec. Surgical Oncology
Volume 12 - 2025 | doi: 10.3389/fsurg.2025.1584200
This article is part of the Research TopicAdvances in Surgical Techniques and ML/DL-based Prognostic Biomarkers for Surgical and Adjuvant Therapies of Hepatobiliary and Pancreatic CancersView all 4 articles
Undifferentiated Carcinoma with Osteoclast-Like Giant Cells of the Pancreas: A Rare Case Report and Review of the Literature
Provisionally accepted
- 1International Medical Department, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China
- 2People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China
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Background: Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas (UC-OGCP) is an exceedingly rare malignant tumour that accounts for less than 1% of all pancreatic nonendocrine neoplasms. Case Presentation: We present a case of UC-OGCP in a 46-year-old male patient who was referred to our hospital after the incidental identification of a cystic tumour in the pancreas. Computed tomography (CT) revealed a 1.4×1.4×1.6-cm mass in the pancreatic head. Surgical resection was performed because it was difficult to determine the degree of malignancy of the tumour through clinical assessment. Intraoperative frozen-section pathology confirmed that the tumour was a malignant neoplasm. Pancreaticoduodenectomy was subsequently conducted. Histopathological studies confirmed the diagnosis of UC-OGCP.The clinical symptoms of UC-OGCP are nonspecific, and there are no distinct serological markers. Diagnosis relies primarily on endoscopic biopsy or postoperative pathology. We report this case of UC-OGCP and provide a literature review on the clinicopathological features, differential diagnosis, treatment, and prognosis of UC-OGCP, aiming to improve the understanding of this disease.
Keywords: Undifferentiated carcinoma, Osteoclast-like giant cells, Pancreas, computed tomography, Immunotherapy
Received: 27 Feb 2025; Accepted: 16 Jun 2025.
Copyright: © 2025 SI, liu, lin, qin, zhang, Deng and lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Demao Deng, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China
zhao lu, International Medical Department, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China
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