ORIGINAL RESEARCH article
Front. Surg.
Sec. Obstetrics and Gynecological Surgery
Volume 12 - 2025 | doi: 10.3389/fsurg.2025.1588498
Perinatal factors for antepartum hemorrhage in women with placenta accreta spectrum
Provisionally accepted
- 1Foshan Women and Children Hospital, Foshan, China
- 2Anhui Medical University, Hefei, Anhui Province, China
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Placenta accreta spectrum with antepartum hemorrhage is closely related to maternal and fetal morbidity and mortality. It is of utmost importance to predict the possibility of antepartum hemorrhage using perinatal factors before delivery in women with placenta accreta spectrum. The aim of this study is to identify the risk factors for antepartum hemorrhage in women with placenta accreta spectrum. This retrospective cohort study evaluated pregnant women with placenta accreta spectrum. Multivariate logistic regression was used to identify the independent variables associated with antepartum hemorrhage and a nomogram was developed to predict the possibility of antepartum hemorrhage. An Excel form computer interface was constructed to use the prediction model. This retrospective cohort study included 188 participants (74 with antepartum hemorrhage). According to multivariate logistic regression analysis, blood type O (odds ratio [OR] 2.277, confidence interval [CI] 1.220-4.250), history of miscarriage (2.178, 95% CI 1.114-4.261), and parity (1.701, 1.037-2.790) were independent risk factors for antepartum hemorrhage in women with placenta accreta spectrum. This results revealed that women with placenta accreta spectrum with blood type O, history of miscarriage, and multiparity may have a significant risk of experiencing antepartum hemorrhage.
Keywords: Placenta accreta spectrum, Antepartum hemorrhage, Placenta Previa, risk factor, nomogram
Received: 06 Mar 2025; Accepted: 11 Jun 2025.
Copyright: © 2025 Hu, Ye, Zhou, Guo and Fan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Dazhi Fan, Foshan Women and Children Hospital, Foshan, China
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