CASE REPORT article
Front. Surg.
Sec. Cardiovascular Surgery
Volume 12 - 2025 | doi: 10.3389/fsurg.2025.1591023
This article is part of the Research TopicExploring New Frontiers in Heart Surgery: Case Studies 2025View all 4 articles
Off-pump CABG is a safe option during pregnancy, where cardiopulmonary bypass (CPB) could pose additional significant surgical risk
Provisionally accepted
- 1Imperial College London, London, United Kingdom
- 2Basınevleri Family Health Center, Ankara, Türkiye
- 3College of Medicine, Ajman University, Ajman, United Arab Emirates
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Off-pump coronary artery bypass grafting (OPCAB) is a surgical technique designed to treat coronary artery disease (CAD) by restoring blood flow to the myocardium through new arterial or venous grafts without the use of cardiopulmonary bypass (CPB). The gold standard conduit, the left internal thoracic artery (LITA), is most commonly anastomosed to the distal left anterior descending (LAD) artery [1], with additional grafts based on anatomical requirements [1,2]. OPCAB offers distinct advantages over traditional on-pump CABG, notably reducing complications such as systemic inflammatory response, neurological deficits, and prolonged recovery [1,2]. It is particularly beneficial in patients at high risk for stroke [3] or renal failure [4].We report a rare case of successful OPCAB in a 27-year-old pregnant woman with homozygous familial hypercholesterolemia (FH) and multivessel CAD during her second trimester. This case underscores the feasibility, safety, and effectiveness of OPCAB in managing complex coronary disease during pregnancy, minimizing maternal and fetal risks associated with CPB.
Keywords: Off pump CABG, Coronary artery bypass and grafting, Cardiothoracic surgery and cardiac surgery, preganacy, Familial Hypercholesterolemia, Coronary Artery Disease, Surgical risk during pregnancy, Pregnancy and cardiovascular disease
Received: 10 Mar 2025; Accepted: 06 May 2025.
Copyright: © 2025 Hasanzade, Ortac, Alkassar, Theodoropoulos and Al Jaaly. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Emad Al Jaaly, Imperial College London, London, United Kingdom
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