ORIGINAL RESEARCH article
Front. Surg.
Sec. Neurosurgery
Volume 12 - 2025 | doi: 10.3389/fsurg.2025.1591985
This article is part of the Research TopicBrain stimulation for cognitive impairments in psychiatric and neurodegenerative disordersView all 3 articles
Peri-Lead Edema in Deep Brain Stimulation: Common Complication or Rare Challenge?
Provisionally accepted
Martin Nevrly
Filip Blazek*
David Krahulik
Pavel OtrubaEva Cechakova
Ahmed Naser Mohamed Afifi
Petr Kanovsky- University Hospital Olomouc, Olomouc, Czechia
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Introduction: Peri-lead edema (PLE) is a commonly observed but often asymptomatic complication of deep brain stimulation (DBS). While usually transient and benign, severe cases of PLE can result in neurological symptoms, impacting patient outcomes. This case series explores the clinical course, management, and outcomes of symptomatic PLE in a series of five patients undergoing DBS. Objective: To analyze the presentation and management strategies for symptomatic peri-lead edema identified in patients undergoing DBS for movement disorders. Methods: A retrospective review of 191 patients who underwent DBS at the University Hospital in Olomouc, Czech Republic, between 2008 and 2024 was conducted. Postoperative imaging and clinical follow-ups were used to identify and evaluate cases of symptomatic PLE. Patients who developed symptomatic PLE were treated with corticosteroids and monitored through imaging and neurological assessments. Results: Among the 191 patients, we identified 5 (2.6 %) who developed symptomatic PLE characterized by cognitive decline, motor disturbances, and, in some cases, pseudocyst formation. Symptoms typically presented several weeks to months postoperatively. Management with corticosteroid therapy resulted in clinical improvement and resolution of edema in all cases. Following the resolution of PLE, DBS therapy was successfully reinitiated, achieving favorable therapeutic outcomes. Conclusions: Symptomatic PLE is a rare but clinically significant complication of DBS. Early detection and timely management with corticosteroids are critical for symptom resolution and successful continuation of DBS therapy. Vigilant postoperative monitoring and further research are essential to improve understanding and management of PLE.
Keywords: Peri-lead edema, Deep Brain Stimulation, neurological complications, Corticosteroid therapy, Postoperative monitoring, Pseudocyst
Received: 11 Mar 2025; Accepted: 07 Aug 2025.
Copyright: © 2025 Nevrly, Blazek, Krahulik, Otruba, Cechakova, Afifi and Kanovsky. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Filip Blazek, University Hospital Olomouc, Olomouc, Czechia
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