ORIGINAL RESEARCH article
Front. Surg.
Sec. Neurosurgery
Volume 12 - 2025 | doi: 10.3389/fsurg.2025.1598385
This article is part of the Research TopicHydrocephalus Volume IIView all 3 articles
White blood cells, monocytes and thrombin time in predicting symptomatic hydrocephalus in patients with aneurysmal subarachnoid hemorrhage
Provisionally accepted
- 1Department of Neurosurgery, Third Affiliated Hospital of Soochow University, Changzhou, China
- 2Department of Endocrinology, Third Affiliated Hospital of Soochow University, Changzhou, China
- 3Department of Imaging, Third Affiliated Hospital of Soochow University, Changzhou, China
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Objective: To investigate the value of admission blood routine and coagulation function parameters in predicting acute symptomatic hydrocephalus in patients with aneurysmal subarachnoid hemorrhage (aSAH).Methods: This retrospective study included 423 patients with aSAH admitted to the Department of Neurosurgery of the Third Affiliated Hospital of Soochow University from November 2013 to September 2020. Demographic, clinical and laboratory data were collected. The patients were divided into hydrocephalus group (n=96) and non-hydrocephalus group (n=327) according to the presence of hydrocephalus on the first head CT. Univariate and multivariate logistic regression analyses were used to determine the independent risk factors for acute symptomatic hydrocephalus after aSAH.Results: Among the 423 aSAH patients, 96 (22.70%) developed acute symptomatic hydrocephalus. Multivariate logistic regression analysis showed that, after adjusting for confounding factors, white blood cells (WBC) (OR = 1.121, 95% CI = 1.067-1.181), monocytes (M) (OR = 2.812, 95% CI = 1.183-6.699), and thrombin time (TT) (OR = 0.843, 95% CI = 0.729-0.948) were independently associated with the development of hydrocephalus. Further analysis of the area under the receiver operating characteristic (ROC) curve indicated that, compared to basic clinical data, the combined prediction model of "basic clinical data + WBC + M + TT" performed better (AUC = 0.728, 95% CI = 0.682-0.769, P = 0.004).Conclusions: The WBC, M and TT within 24 h of admission in aSAH patients can be used to predict the occurrence of acute symptomatic hydrocephalus.
Keywords: aneurysmal subarachnoid Hemorrhage, Acute symptomatic hydrocephalus, white blood cells, Monocytes, Thrombin Time
Received: 08 Apr 2025; Accepted: 16 Jun 2025.
Copyright: © 2025 Deng, Yang, Chen, Xing and Shi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wei Xing, Department of Imaging, Third Affiliated Hospital of Soochow University, Changzhou, China
Jia Shi, Department of Neurosurgery, Third Affiliated Hospital of Soochow University, Changzhou, China
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