Abstract
Introduction:
Temple augmentation has become a cornerstone in full-face aesthetic rejuvenation, yet traditional techniques often face limitations, including aesthetic limitations and the risk of vascular complications. This study explores a novel interfascial injection technique, aiming to improve both the safety and efficacy of soft tissue fillers in the temporal region by leveraging anatomical knowledge.
Materials and methods:
A total of n = 20 female patients, aged 26–75, received injections using Ultra Volume Rennova®, a high-viscoelastic dermal filler. The filler was administered with a 22G × 5 cm cannula into the interfascial plane, located between the superficial and deep temporal fascia. Ultrasound imaging was used to confirm accurate filler placement. The access point for injections was the infrazygomatic arch, targeting the anterior third of the temporal region.
Results:
Favorable outcomes in terms of volumization and lifting effects in the upper third of the face were reported in all patients. Fifteen patients reported mild pain post-injection, and two reported moderate pain, with no serious adverse events or hematomas observed.
Conclusion:
This interfascial injection technique offers a safer and more effective alternative to traditional subcutaneous or supraperiosteal methods. By leveraging the anatomical relationship between the zygomatic arch and the deep temporal fascia, the procedure reduces the risk of vascular complications while achieving natural and lasting aesthetic results. Further studies are warranted to validate these findings and assess long-term outcomes.
Highlights
A novel interfascial injection technique was developed for the temporal region, enhancing safety by reducing the risk of vascular complications while delivering natural volumization and lifting effects.
In a study involving 20 patients, no serious adverse events occurred, with minimal pain reported, underscoring the technique's safety and efficacy.
This method optimizes filler placement by utilizing the continuity between the zygomatic arch periosteum and deep temporal fascia, allowing safe access via the zygomatic arch. It offers a superior alternative to subcutaneous or supraperiosteal injections, potentially improving outcomes in facial rejuvenation procedures.
Introduction
Facial rejuvenation through minimally invasive procedures has gained popularity due to its ability to deliver natural-looking results with minimal downtime. The temporal region – initially often neglected by both patients and aesthetic providers – receives an increasing amount of attention as its importance in the overall aesthetic perception is being recognized (, ). Traditional methods of filler injections in the temporal area including subcutaneous and supraperiosteal injections often faced challenges in achieving optimal outcomes due to safety concerns and anatomical limitations. Specifically, the risk of vascular complications, such as vision loss following arterial injections, necessitated a reevaluation of the injection techniques ().
In this study, we present a novel technique that leverages regional anatomical principles to target the interfascial plane—a potential space of loose areolar connective tissue between the superficial and deep temporal fasciae. This approach aims to enhance treatment efficacy in the temporal region while improving safety by minimizing the risk of injury to critical vascular structures, such as the superficial temporal artery, thereby providing aesthetic practitioners with a method grounded in anatomical precision.
Materials and methods
This prospective study included a cohort of 20 female patients, aged between 26 and 75 years, who underwent temple augmentation with an advanced high-viscoelastic dermal filler. This study was conducted in a private clinical setting as part of routine facial rejuvenation procedures and internal quality assurance. All patients provided written informed consent for both the treatment and the anonymized use of their clinical data, including photographic and ultrasonographic documentation, for scientific publication. No investigational product was used; all treatments involved a commercially available hyaluronic acid filler designed for deep tissue integration and structural support (Ultra Volume Rennova, Rennova®, Goiânia, Brazil). According to national regulations in Brazil and prevailing ethical standards for private clinical practice, retrospective analysis of anonymized data collected for quality monitoring and educational purposes does not require formal IRB approval. The study was conducted in accordance with the ethical principles outlined in the Declaration of Helsinki.
The filler was delivered using a 22G × 5 cm blunt-tip cannula (Rennova®, Goiânia, Brazil), allowing for atraumatic distribution of the product within the targeted anatomical compartment. All injections were meticulously administered within the interfascial plane, anatomically defined as the space between the superficial temporal fascia and the deep temporal fascia, which is composed of loose areolar tissue. Although the superficial and deep temporal fasciae fuse at the superior zygomatic arch, they separate immediately superior to the arch, creating an interfascial compartment of loose connective tissue (). This plane is of particular clinical interest due to its capacity for accommodating volumetric augmentation while minimizing the risk of vascular compromise or irregular contouring. A 22G 50 mm cannula was inserted at the entry point on the superior border of the zygomatic arch between the medial and its central third on the longitudinal way. The cannula was inserted at the entry point at an angle of 90 degrees; initially the tip of the cannula touched the periosteum of the zygomatic arch and only then was directed towards the temporal region. After entering the temple in the interfascial layer, the cannula was guided towards the temporal crest and then retracted to the central region of the temple where a bolus injection of around 0.2 ml of hyaluronic acid was made.
To ensure accuracy and reproducibility, real-time ultrasonographic imaging was employed to confirm the precise localization of the filler within the interfascial space. High-resolution ultrasound visualization was performed in accordance with standardized imaging protocols, allowing for verification of the injection plane, assessment of filler distribution, and exclusion of inadvertent vascular compromise. More specifically, using an 18 MHz “hockey stick” transducer (GE L8-18i-SC 8–18 MHz California-USA) coupled to the GE Logic Ultrasound (NextGen, California-USA, 2023), mapping was performed. The patient was placed on a stretcher in the supine position. The temporal region was cleaned using sterile gauze and a 3% aqueous chlorhexidine solution. (Riohex, Rioquimica, Brasil). The 8–18 Hz hockey stick probe was placed longitudinally parallel and right above to the cannula starting from the entry point at the zygomatic arch to the temporal crest. The lubricant gel used for the examination was a sterile gel (Sterile Aquasonic Ultrasonic gel, PARKER, Brazil), to avoid contamination of the entry site and the video recording was made with the probe stationary in the same longitudinal direction. The transducer was placed in B-mode initially to map all anatomical structures, followed by power Doppler mode to visualize vascular structures and confirm a safe injection corridor. Finally, the location and planes were marked in mm according to its distance from the supraperiosteal plane at a 90-degree angle and differentiated between them. Real-time ultrasonography was used to verify that the filler appeared as an anechoic layer between the two hyper-echoic fascial planes (Figures 1, 2 and Supplementary Video S1).
Figure 1
Figure 2
Results
The results of the study were promising, both in terms of volumization and lifting effects (Figure 3). In all patients, real-time ultrasound confirmed that the filler was deposited within the interfascial layer between the superficial and deep temporal fascia. This was documented in Supplementary Video S1, which demonstrates a representative case of successful cannula guidance and filler distribution within the intended anatomical plane. Vector images demonstrated a clear lifting effect in the upper third of the face, particularly in the temporal region. Volume images further corroborated the effectiveness of this technique in restoring lost volume (Figure 4).
Figure 3
Figure 4
In terms of patient safety, the procedure demonstrated a favorable safety profile. Eighteen patients reported mild pain within 48 h post-injection, while two patients experienced moderate pain. Notably, no patients reported any hematomas or other serious adverse events.
Discussion
The temporal region is vital to facial rejuvenation as it supports the upper third of the face, but its complex anatomy presents unique challenges for safe and effective aesthetic treatments. Previous literature has identified up to 13 distinct layers in this region, showing intricate anatomical relationships with vascular structures, including the superficial and deep temporal arteries (). This complexity increases the risk of accidental intravascular injections, vascular occlusion and subsequent ischemic complications, such as vision loss. Traditional injection techniques, whether subcutaneous or supraperiosteal, not only pose these significant risks but also have aesthetic limitations.
Subcutaneous injections may risk inadvertently entering the superficial temporal fascia, which contains the superficial temporal artery, potentially leading to vascular injury. Additionally, in cases of severe temporal hollowing, superficial injections often yield unsatisfactory results, as the filler may be visible under the skin due to insufficient tissue coverage. On the other hand, supraperiosteal injections, while capable of substantial volume restoration, carry a great risk of injuring the deep temporal arteries, and filler displacement due to contractions of the temporalis muscle (). Moreover, they require a larger volume of product to achieve noticeable surface effects, further complicating the procedure (, ).
To overcome these limitations, we propose an interfascial approach that involves injecting the filler between the subcutaneous and supraperiosteal layers. This technique seeks to optimize both safety and efficacy by minimizing the risk of vascular complications and reducing muscle-related displacement. It offers a balanced solution, delivering a noticeable surface effect while ensuring sufficient soft tissue coverage to prevent product visibility. The interfascial layer offers a reproducible and safe environment for filler placement. Notably, recent studies also documented the feasibility and safety of injections between the superficial and deep temporal fasciae: Lee et al. found that filling the interfascial layer is “relatively safe and easy” and Cohn et al. similarly advocate this plane as a safe, efficacious target (, ).
An integral aspect of our technique is establishing bone contact at the zygomatic arch to ensure correct placement within the interfascial layer. The anatomical continuity between the periosteum of the zygomatic arch and the deep temporal fascia guides the cannula into the intended anatomical plane, allowing for safe and accurate filler deposition that mimics the natural contours of the face while minimizing the risk of arterial injury or product migration (, ).
Additionally, the interfascial plane provides an ideal environment for high-viscoelastic fillers, such as Ultra Volume Rennova®, which are well-suited for tissue volumization and lifting, ensuring that the filler maintains its shape and volume over time without the risk of deformation or displacement. In terms of patient safety, the low incidence of adverse events observed in this study, including minimal reports of pain and no hematomas, highlights the tolerability of the interfascial approach. The use of ultrasound imaging to confirm the injection plane further enhances safety by ensuring precise filler placement. However, we acknowledge that differentiating between the superficial and deep temporal fascia using ultrasound may be challenging in certain cases, particularly due to variations in adipose thickness and acoustic window quality (, ).
Conclusion
The interfascial injection technique described in this study offers a novel and effective approach to facial rejuvenation, particularly in the anatomically and aesthetically challenging temporal region. By leveraging the anatomical relationship between the zygomatic arch and the deep temporal fascia, this technique provides a safer, more efficient, and aesthetically superior alternative to traditional subcutaneous and supraperiosteal injections. The results of this study demonstrate the efficacy of this approach in achieving both lifting and volumization, while maintaining a favorable safety profile. Further studies with larger patient populations are warranted to confirm these findings and to explore the long-term effects of this technique in facial rejuvenation.
Statements
Data availability statement
The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author.
Ethics statement
Ethical approval was not required for the study involving humans in accordance with the local legislation and institutional requirements. Written informed consent to participate in this study was not required from the participants or the participants' legal guardians/next of kin in accordance with the national legislation and the institutional requirements. Written informed consent was obtained from the individual(s), and minor(s)' legal guardian/next of kin, for the publication of any potentially identifiable images or data included in this article.
Author contributions
BB: Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft. LG: Investigation, Supervision, Writing – review & editing. BG: Data curation, Formal analysis, Investigation, Writing – review & editing. GA: Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Writing – original draft.
Funding
The author(s) declare that financial support was received for the research and/or publication of this article. The authors received financial support from Rennova® for the research and publication of this article. The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article, or the decision to submit it for publication. The products utilized in this study were donated by the injectors for the purposes of this study.
Conflict of interest
BB is a medical consultant and speaker for Rennova®, Allergan Aesthetics, Merz Aesthetics®, and L'Oréal. GA is a medical speaker for Rennova®.
The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Generative AI statement
The author(s) declare that no Generative AI was used in the creation of this manuscript.
Any alternative text (alt text) provided alongside figures in this article has been generated by Frontiers with the support of artificial intelligence and reasonable efforts have been made to ensure accuracy, including review by the authors wherever possible. If you identify any issues, please contact us.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Supplementary material
The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fsurg.2025.1603177/full#supplementary-material
Supplementary Video S1The video illustrates the live advancement of the cannula through the interfascial plane between the superficial and deep temporal fascia, followed by hyaluronic acid deposition. The visualized anechoic filler layer between two hyperechoic fascial boundaries confirms precise interfascial entry and distribution.
References
1.
RihaniJ. Aesthetics and rejuvenation of the temple. Facial Plast Surg. (2018) 34(02):159–63. 10.1055/s-0038-1636921
2.
Aesthetic Plastic Surgery National Databank Statistics 2022. Aesthet Surg J. (2023) 43(Suppl 2):1–19. 10.1093/asj/sjad354
3.
TabatabaeiFSAzimiATabatabaeiSSPakdamanH. Recovery of acute ophthalmoplegia after hyaluronic acid filler injections to the temples: a case report and review of the literature. Arch Plast Surg. (2022) 50(2):148–52. 10.1055/s-0043-1761211
4.
DesyatnikovaS. Ultrasound-Guided Temple filler injection. Facial Plast Surg Aesthet Med. (2022) 24(6):501–3. 10.1089/fpsam.2022.0176
5.
IngallinaFAlfertshoferMGSchelkeLVelthuisPJFrankKMardiniSet alThe fascias of the forehead and temple aligned—an anatomic narrative review. Facial Plast Surg Clin North Am. (2022) 30(2):215–24. 10.1016/j.fsc.2022.01.006
6.
BaeHChoiYJLeeKLGilYCHuKSKimHJ. The deep temporal arteries: anatomical study with application to augmentations procedures of the temple. Clin Anat. (2023) 36(3):386–92. 10.1002/ca.23952
7.
CotofanaSKobanKCKonstantinFGreenJBEtzelLGiuntaREet alThe surface-volume coefficient of the superficial and deep facial fat compartments: a cadaveric three-dimensional volumetric analysis. Plast Reconstr Surg. (2019) 143(6):1605–13. 10.1097/PRS.0000000000005524
8.
CotofanaSGaeteAHernandezCACasabonaGBaySPavicicTet alThe six different injection techniques for the temple relevant for soft tissue filler augmentation procedures—clinical anatomy and danger zones. J Cosmet Dermatol. (2020) 19(7):1570–9. 10.1111/jocd.13491
9.
CohnJEPionTGrecoTM. Not above, not below: right in the middle!-novel filler technique for temporal augmentation and rejuvenation. Facial Plast Surg. (2020) 36(5):623–7. 10.1055/s-0040-1709710
10.
LeeWParkJWYangEJ. Temple augmentation by injecting a hyaluronic acid filler between the superficial and deep temporal fasciae. J Cosmet Dermatol. (2022) 21(10):4313–8. 10.1111/jocd.15004
11.
HwangKKimDJ. Attachment of the deep temporal fascia to the zygomatic arch: an anatomic study. J Craniofac Surg. (1999) 10(4):342–5. 10.1097/00001665-199907000-00012
12.
YiKHWanJKimSBKimHJ. Temporal fat pad filler injection for lifting purposes: shifting of the superficial layer of deep temporal fascia. J Cosmet Dermatol. (2025) 24(3):e70023. 10.1111/jocd.70023
13.
KimSBHuHBaeHYiKH. Anatomy of the temporal region to guide filler injections. Surg Radiol Anat. (2024) 46(5):615–24. 10.1007/s00276-024-03340-x
Summary
Keywords
temple augmentation, soft tissue fillers, facial anatomy, hyaluronic acid, facial rejuvenation
Citation
Bravo BSF, Gonçalves Bravo L, Gouvea BF and Alves GLT (2025) Leveraging anatomy to improve safety and efficacy in temple augmentations—a case series of 20 patients. Front. Surg. 12:1603177. doi: 10.3389/fsurg.2025.1603177
Received
31 March 2025
Accepted
29 August 2025
Published
25 September 2025
Volume
12 - 2025
Edited by
Jeremie Oliver Piña, National Institutes of Health (NIH), United States
Reviewed by
Davide De Cicco, Istituto Stomatologico Italiano, Italy
Soobin Kim, Wonkwang University, Republic of Korea
Updates
Copyright
© 2025 Bravo, Gonçalves Bravo, Gouvea and Alves.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Bruna S. F. Bravo brunabravo@bravomed.com.br
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.