REVIEW article
Front. Surg.
Sec. Visceral Surgery
Volume 12 - 2025 | doi: 10.3389/fsurg.2025.1603704
This article is part of the Research TopicThe Evolving Role of Liver Transplantation for the treatment of Malignant Tumors: Current Perspectives and Future DirectionsView all articles
Liver Transplantation for the Treatment of Neuroendocrine Liver Metastases
Provisionally accepted
- 1University of Kentucky HealthCare, Lexington, United States
- 2Oregon Health and Science University, Portland, Oregon, United States
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Neuroendocrine liver metastases (NELM) are commonly observed in patients with advanced neuroendocrine tumors (NETs) and are associated with poor prognosis, primarily due to liver failure and hormone-related complications. While hepatic resection remains the standard surgical approach, orthotopic liver transplantation (OLT) has emerged as a potentially curative treatment in selected patients with unresectable disease.This review summarizes current evidence on the role of OLT in managing NELM, with a focus on patient selection criteria and existing clinical guidelines. Appropriate selection is essential, as improved long-term survival has been consistently demonstrated in patients who meet established eligibility parameters.In conclusion, OLT offers meaningful survival benefits for carefully selected patients with NELM. A multidisciplinary approach and ongoing research into prognostic markers and adjunctive therapies are critical to optimizing outcomes in this challenging clinical setting.
Keywords: neuroendocrine neoplasia, Liver metastasases, liver transplant, liver resection, neuroendocrine (D018278)
Received: 31 Mar 2025; Accepted: 09 Jun 2025.
Copyright: © 2025 Gedaly, Orozco, Ramaiah, Cracco and Desai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Roberto Gedaly, University of Kentucky HealthCare, Lexington, United States
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