ORIGINAL RESEARCH article
Front. Surg.
Sec. Surgical Oncology
Volume 12 - 2025 | doi: 10.3389/fsurg.2025.1608312
This article is part of the Research TopicExtending the Limit of Liver Cancer Treatment with Surgical OptionsView all 6 articles
Efficacy and safety of biliary stenting combined with 125 I seed implantation for the treatment of advanced extrahepatic cholangiocarcinoma
Provisionally accepted
- 1Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
- 2Thirteenth People's Hospital of Chongqing, Chongqing, Chongqing Municipality, China
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Background: The implantation of 125I seed is expected to improve the prognosis of patients undergoing stent placement for advanced extrahepatic cholangiocarcinoma (eCCA), but its efficacy and safety remain unclear. Methods: Forty advanced eCCA patients who received percutaneous transhepatic biliary stenting (PTBS) (control group) and 40 PTBS combined with 125I seed implantation (125I group) were retrospectively analyzed. Changes in serum biochemical indicators and tumor markers as well as the occurrence of complications were observed in the two groups, and the durations of stent patency and survival were compared. Results: The general information and preoperative baseline data did not significantly differ between the two groups (P < 0.05). Regardless of whether PTBS was combined with 125I seed implantation, the ALT/AST levels of patients after operation were significantly lower, jaundice was relieved. And the improvements in postoperative liver function and jaundice in patients in 125I group were better than those in control group. In addition, tumor markers in the two groups decreased significantly, and the decrease was more significant in patients in 125I group. There was no significant difference in the total complication rate between the two groups. The stent patency time and overall survival of the patients in the 125I group were longer than those in control group. Conclusion: Biliary stenting combined with 125I seed implantation is a safe and effective treatment for patients with advanced eCCA, and it is superior to biliary stenting alone in improving liver function and prolonging the duration of stent patency and survival time.
Keywords: Extrahepatic cholangiocarcinoma, 125 I seed implantation, Biliary stenting, Stent patency time, Postoperative survival
Received: 08 Apr 2025; Accepted: 08 Sep 2025.
Copyright: © 2025 Cheng, Wang, Miao and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shengwei Li, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
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