MINI REVIEW article
Front. Surg.
Sec. Thoracic Surgery
Volume 12 - 2025 | doi: 10.3389/fsurg.2025.1643120
This article is part of the Research TopicThe Emerging Role of Biomarker Mutations in Early Stage Non-small Cell Lung Cancer (NSCLC) ManagementView all articles
KIAA1429 in Non-Small Cell Lung Cancer: Bridging m6A Epigenetics to Therapeutic Innovation
Provisionally accepted
- 1Beilun District People's Hospital of Ningbo, Ningbo, China
- 2Honghu People's Hospital, Jingzhou, China
- 3Taihe Hospital, Hubei University of Medicine, Shiyan, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
As a pivotal component of the m6A methyltransferase complex, KIAA1429 plays a critical regulatory role in the pathogenesis of non-small cell lung cancer (NSCLC), driving tumorigenesis, metastasis, and therapeutic resistance through epigenetic mechanisms. Clinically, KIAA1429 overexpression correlates with aggressive disease progression and poor patient prognosis to conventional therapies. This review comprehensively examines the dysregulated expression patterns and functions of KIAA1429 in NSCLC, elucidating its m6A-dependent modulation of key downstream effectors (Such as the HOXA1, DAPK3, and BTG2) that orchestrate malignant transformation. We highlight the emerging potential of KIAA1429 as a novel molecular target for precision therapy in NSCLC.
Keywords: KIAA1429, m6A modification, Non-small cell lung cancer, molecular target, Gefitinib resistance, epigenetic therapy
Received: 08 Jun 2025; Accepted: 18 Aug 2025.
Copyright: © 2025 Shi, You, Ren, Guo and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Dan Li, Taihe Hospital, Hubei University of Medicine, Shiyan, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.