ORIGINAL RESEARCH article
Front. Surg.
Sec. Orthopedic Surgery
Volume 12 - 2025 | doi: 10.3389/fsurg.2025.1652156
This article is part of the Research TopicDiagnosis and Treatment in Age-related musculoskeletal disordersView all 14 articles
Oral eupolyphaga sinensis extract promotes lumbar interbody fusion by enhancing vascularization of cartilage endplate
Provisionally accepted
- 1The First hospital of Hebei Medical University, Shijiazhuang, China
- 2The Third Hospital of Hebei Medical University, Shijiazhuang, China
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Objective: This study aims to investigate the effect of oral Eupolyphaga Sinensis (ES) extract on intervertebral fusion in a rabbit model. Methods: A rabbit lumbar lateral interbody fusion model was established. Different treatments were administered to each group, including the control group (CON), oral ES extract group (ES), interbody fusion group (IBF) and interbody fusion combined with oral ES group (IBF/ES). Ten weeks after surgery, micro-CT was used to assess intervertebral bone fusion. Bone trabecula parameters, including bone volume fraction (BV/TV), trabecular number (Tb.N) and trabecular thickness (Tb.Th), were measured. Histological analyses, including Masson and HE staining, were used to evaluate angiogenesis and bone growth in the endplate. Results: The micro-CT at the 10th postoperative week showed significant bone tissue regeneration and stable fusion in the IBF/ES groups. Fusion scores, BV/TV, Tb.N and Tb.Th were significantly higher in the IBF/ES groups compared to the other groups. In addition, Masson and HE staining indicated evident vascular ingrowth and new bone formation after oral ES extract treatment. Among the four groups, the IBF/ES groups showed the most significant bone formation and the best fusion effect. Conclusion: This study suggested that oral ES extract after spine surgery can significantly enhance the effectiveness and success rate of lumbar lateral fusion surgery by promoting endplate vascularization and bone formation.
Keywords: Eupolyphaga sinensis, Cartilage endplate, Angiogenesis, Interbody fusion, Spine, rabbit
Received: 23 Jun 2025; Accepted: 07 Aug 2025.
Copyright: © 2025 Zhen, Li, Li, Wu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wei Zhang, The Third Hospital of Hebei Medical University, Shijiazhuang, China
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