ORIGINAL RESEARCH article
Front. Surg.
Sec. Orthopedic Surgery
Volume 12 - 2025 | doi: 10.3389/fsurg.2025.1654648
This article is part of the Research TopicAdvancing Musculoskeletal Health: Bridging Basic and Clinical Research on Biomechanical Properties of Joints, Ligaments, Tendons, and Associated StructuresView all 8 articles
Surgical Repair of Acute Achilles Tendon Rupture With and Without Human Amniotic Membrane Augmentation: A Retrospective Comparative Study
Provisionally accepted
- 1Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan
- 2Tajen University, Yanpu, Taiwan
- 3National Sun Yat-sen University, Kaohsiung, Taiwan
- 4Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan
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Objectives: Achilles tendon ruptures are common, particularly in active individuals; however, optimal healing remains challenging due to limited vascularity, adhesions, and re-rupture risk. Human amniotic membrane (hAM), rich in extracellular matrix and bioactive factors, shows regenerative potential, offering a promising adjunct for tendon repair. Methods: After institutional review board approval, patients aged 20–75 years who underwent end-to-end Achilles tendon repair for acute complete rupture between February 2019 and January 2025 were retrospectively reviewed. Patients were grouped by intraoperative use of hAM allografts. Baseline characteristics, rupture location, operative time, complications (tendon re-rupture, wound infection, dehiscence), American Orthopaedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot score, and follow-up duration were analyzed using t-tests and Fisher's exact tests (p < 0.05). Results: In total, 45 repairs were performed in 44 patients. Of these, 13 patients (13 feet) received hAM augmentation, while 31 patients (32 feet)
Keywords: Achilles tendon rupture, Amniotic membrane, biological augmentation, Tendon healing, orthopedic surgery, Regenerative Medicine
Received: 26 Jun 2025; Accepted: 25 Sep 2025.
Copyright: © 2025 Wei, Chien, Kuo and Chou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yi Ping Wei, weiy8242@gmail.com
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