CASE REPORT article
Front. Surg.
Sec. Otorhinolaryngology - Head and Neck Surgery
Diagnosing and Treating Sinonasal Glomangiopericytoma: A Case Study
Provisionally accepted
- The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Background: sinonasal glomangiopericytoma(SNGP) is a rare neoplasm with distinct clinical and pathological characteristics, typically presenting in the sinonasal region and accounting for less than 0.5% of all sinonasal tumors. This case report describes a 74-year-old male with SNGP and reviews the relevant literature to enhance understanding and management of this rare entity. Case Presentation: The patient presented with a one-year history of intermittent left-sided epistaxis and decreased left nasal olfaction. Imaging studies revealed a mass in the left nasal cavity, and endoscopic sinus surgery was performed, with pathology confirming SNGP. Immunohistochemistry results were consistent with SNGP, showing positive staining for SMA, F8, CD99, cyclin D1, β-catenin and negative for Bcl-2, Ki67 and CD117. The treatment involved a comprehensive surgical approach, where the tumor was completely resected. Postoperatively, the patient did not receive any adjuvant therapy, and regular follow-ups were conducted to monitor for recurrence or metastasis. Conclusion: SNGP, when completely resected, has a favorable prognosis. This case highlights the critical role of histopathological examination and immunohistochemistry in diagnosing SNGP. The patient has been followed up for over three years with no signs of tumor recurrence or distant metastasis, indicating the effectiveness of the surgical intervention and the benign nature of the tumor. The importance of long-term follow-up is emphasized to monitor for potential recurrences, given the indolent biological behavior of SNGP. This case underscores the significance of a multidisciplinary approach, including surgery and pathology, in achieving optimal outcomes for patients with SNGP.
Keywords: Sinonasal glomangiopericytoma, Endoscopic sinus surgery, Immunohistochemistry, a case study, Diagnosing and Treating
Received: 07 Jul 2025; Accepted: 26 Nov 2025.
Copyright: © 2025 Wang, Ye, Shi and Yin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Min Yin
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