SYSTEMATIC REVIEW article
Front. Surg.
Sec. Reconstructive and Plastic Surgery
Volume 12 - 2025 | doi: 10.3389/fsurg.2025.1666776
This article is part of the Research TopicSurgical Innovations in the Management of Chronic WoundsView all articles
Adipose Tissue and Fat-Derived Products in Wound, Ulcer, and Scar Management: A Systematic Review
Provisionally accepted
- 1Faculty of Medicine, Hashemite University, Zarqa, Jordan
- 2Jordanian Royal Medical Services, Amman, Jordan
- 3Universidade de Sao Paulo, São Paulo, Brazil
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Adipose-derived therapies hold promise in addressing the increasing prevalence of skin wounds, scars, and ulcers. This systematic review, conducted following the PRISMA guidelines, evaluates the therapeutic potential of adipose derived stem cells for improving wound healing, scar development and ulcer management. An extensive search was conducted across PubMed, EMBASE, Scopus, Web of Science, Cochrane Central, and LILACS. The search strategy employed a combination of keywords and Medical Subject Headings (MeSH) terms related to "adipose tissue", "fat derivatives", "ulcers", "wound healing", and their synonyms, covering articles published from inception to October 2024. Our search yielded 589 records, with 16 randomized clinical trials and two ongoing studies meeting inclusion criteria after screening and full-text assessment. Findings indicate that adipose-derived therapies significantly enhance wound healing, reduce pain, and improve cosmetic appearance, patient satisfaction, and health-related quality of life compared to conventional treatments. These therapies demonstrate efficacy across various wound types and scars, with a favorable safety profile. However, further standardized protocols and large-scale randomized trials are essential to validate these outcomes and assess long-term safety. While adipose-derived therapies show promise in enhancing wound healing and managing scars, ongoing research is essential to facilitate their integration into routine clinical practice.
Keywords: Adipose Tissue, Fat-derived products, Wound Healing, Ulcer treatment, scar management, Regenerative Medicine
Received: 15 Jul 2025; Accepted: 24 Sep 2025.
Copyright: © 2025 Sbitan, Qandah, Alzraikat and Camargo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Asem Qandah, asems@hu.edu.jo
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