ORIGINAL RESEARCH article
Front. Surg.
Sec. Visceral Surgery
Analysis of Risk Factors Associated with the Development and Postoperative Complications of Complicated Acute Appendicitis in Elderly Patients
Provisionally accepted
- Department of Emergency, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China
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Objective: Based on an analysis of large-scale retrospective case data, this study aimed to identify the risk factors associated with the development and postoperative complications of complicated acute appendicitis (CAA) in elderly patients (>60 years). Methods: A total of 296 elderly patients diagnosed with acute appendicitis (AA) and who underwent appendectomy at our hospital between January 2020 and January 2025 were enrolled in this study. These patients were categorized into either the CAA group (n=113) or the uncomplicated acute appendicitis (UCAA) group (n=183), based on the severity of their clinical presentation. Subsequently, univariate and multivariate logistic regression analyses were performed to identify the risk factors associated with the onset of CAA and its postoperative complications. Results: Elderly patients in the CAA group exhibited a higher risk of postoperative complications and intensive care unit (ICU) admission, as well as prolonged hospitalization, compared to those in the UCAA group. Preoperative abdominal pain lasting more than 3 days [odds ratio (OR)=3.159, P=0.038], the presence of abdominal muscle tension (OR=2.297, P=0.007), appendiceal fecalith (OR=2.697, P=0.002), temperature ≥37.45°C (OR=2.968, P=0.001), neutrophil percentage ≥ 82.7% (OR=2.593, P=0.010), and C-reactive protein (CRP) level ≥4.3mg/L (OR=3.256, P<0.001) were identified as independent risk factors associated with the development of CAA. The incidence of postoperative complications in the CAA group among elderly patients was 31%, which was significantly higher than the 6.0% observed in the UCAA group. Analysis based on CAA patients indicated that the presence of nausea/vomiting (OR=3.629, P=0.033), WBC ≥14.24×109/L (OR=3.825, P=0.021), neutrophil percentage ≥ 84.3% (OR=11.165, P=0.012), and open appendectomy (OR=5.799, P=0.002) were independent risk factors for postoperative complications. Conclusions: Abdominal signs and symptoms, the presence of appendicoliths, and the levels of body temperature, neutrophil, and CRP were associated with the occurrence of CAA, while surgical approaches, the levels of WBC and neutrophil were associated with postoperative complications. This study explored the risk factors associated with CAA and its postoperative complications in elderly patients, thereby offering valuable insights for the clinical management and treatment of AA in this population.
Keywords: acute appendicitis, complicated, Elderly, Postoperative Complications, Risk factors
Received: 25 Jul 2025; Accepted: 10 Nov 2025.
Copyright: © 2025 Jin, Zhang and Cai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Huazhong Cai, caihz021@ujs.edu.cn
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