CASE REPORT article
Front. Surg.
Sec. Surgical Oncology
Volume 12 - 2025 | doi: 10.3389/fsurg.2025.1682095
This article is part of the Research TopicProgress of New Technologies in Gastric Cancer Minimally Invasive TreatmentsView all 4 articles
The successful management of a cardia hamartomatous inverted polyp (CHIP) via endoscopic submucosal dissection: a case report
Provisionally accepted
- 1Lu'an People's Hospital, Anhui, China
- 2Anhui Provincial Hospital, Hefei, China
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Abstract Background A gastric hamartomatous inverted polyp (GHIP) is an uncommon submucosal neoplasm that is histopathologically defined by a submucosal inverted growth of cystically dilated hyperplastic gastric glands. Case presentation A 74-year-old Chinese man presented with a submucosal tumor (SMT) in the cardia, identified through electronic gastroscopy. This report presents a case of cardia hamartomatous inverted polyp (CHIP), which represent a rare histological variant of gastric polyps that pose diagnostic challenges. The endoscopic examination revealed the presence of a submucosal tumor, and endoscopic ultrasonography indicated a heterogeneous tumor predominantly situated within the third (submucosal) layer. Immunohistochemistry outcomes indicated MUC5AC (+), MUC6 (+), Syn (+), Ki-67 (+, approximately 5%), Desmin(+), SMA (+), as well as MUC2 (-). To achieve en bloc resection for lesions >1.0 cm, endoscopic submucosal dissection (ESD) was performed. The pathological evaluation confirmed the diagnosis of CHIP. The patient was discharged without experiencing any complications. Conclusion Therefore, the ESD approach may be particularly suitable for the management of SMT-type hamartomatous inverted polyps.
Keywords: cardia hamartomatous inverted polyp, Submucosal tumor, Endoscopic Submucosal Dissection, gastric cancer, Endoscopic treatment
Received: 08 Aug 2025; Accepted: 18 Sep 2025.
Copyright: © 2025 Zhang, Pan, Liu and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiaoyan Liu, lxyy2024@126.com
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