ORIGINAL RESEARCH article
Front. Surg.
Sec. Neurosurgery
A Comparative Analysis of Outcomes in Patients with Aneurysmal Subarachnoid Hemorrhage Based on Surgical Timing
Provisionally accepted
- 1Jining First People's Hospital, Jining, China
- 2Jining Medical University Clinical Medical College, Jining, China
- 3The Second Affiliated Hospital of Shandong First Medical University, Tai'an, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Purpose: The objective of this study is to investigate the optimal timing of intervention therapy for aneurysmal subarachnoid hemorrhage (aSAH). This research aims to analyze the impact of early treatment and various intervention modalities on clinical outcomes in patients presenting with aSAH. Materials and methods: Patients with aSAH were analyzed for demographics, Fisher grading, WFNS grading, and Hunt-Hess grading. The modified Rankin Scale (mRS) compared outcomes between groups receiving clamping or embolization within 12 hours versus later. Logistic regression evaluated factors affecting mRS prognosis at 3 months post-discharge. Results: This study included 226 patients, with 192 (85%) receiving embolization and 34(15%) patients underwent clipping. 58 (26%) treated within 12 h of aSAH onset and 168 patients received treatment after 12 hours. No significant mRS differences were found between clamping and embolization. Predictors of length of hospitalization were predicted by age, Modified Fisher classification, WFNS classification, Hunt-Hess classification, complications, and intervention time under 12 hours. Early intervention <12h significantly affected the favorable outcome of mRS (0-2) after at 3 months post-discharge; higher admission score, advanced age, and the presence of complications were associated with poor prognosis. Conclusion: Early treatment within 12 hours leads to improved clinical outcomes over delayed treatment.
Keywords: Timing of surgery, ASAH, time window, Treatment modalities, prognosis
Received: 08 Aug 2025; Accepted: 10 Nov 2025.
Copyright: © 2025 Wang, Zhai, Liao, Cui, Wu and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Qingjian Wu, wqw110@163.com
Liangzhen Zhu, zhuliangzhen@163.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.