CASE REPORT article
Front. Surg.
Sec. Pediatric Orthopedics
Volume 12 - 2025 | doi: 10.3389/fsurg.2025.1689110
This article is part of the Research TopicFractures and Deformities of the Extremities in Children and Adolescents: Etiology, Diagnosis, and Treatment: 2025View all 12 articles
Hereditary multiple osteochondromas in a child: A case report and discussion on postoperative complication management
Provisionally accepted
- Jinan Children's Hospital, Jinan, China
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Background: The pathogenesis of hereditary multiple exostoses is mainly related to genetic variants and often requires surgical resection when it causes clinical symptoms. This case report describes a variant in the EXT1 gene and the management of postoperative femoral artery rupture. Case Presentation: We present a case of a 11-year-old boy, who developed hereditary multiple exostoses. The patient presented with multiple bone swellings throughout the body and difficulty squatting on the right thigh. Genetic testing showed that the child had a heterozygous variant in the EXT1 gene c.1722+1G>A (p.?). We performed resection of osteochondroma of the right femur but after surgery there was persistent bleeding from the wound. Surgical exploration revealed a rupture of the right femoral artery, which we repaired. Conclusions: The diagnosis of hereditary multiple exostoses relies on clinical examination and genetic testing. Surgical resection is indicated for symptomatic cases with functional impairment. To prevent vascular injuries such as femoral artery rupture, meticulous surgical technique is essential, including thorough smoothing of the resected bone surface and careful intraoperative assessment of adjacent neurovascular structures. In cases of postoperative bleeding or suspected pseudoaneurysm, prompt imaging and surgical exploration are critical for timely vascular repair.
Keywords: Hereditary multiple osteochondromas, EXT1 gene, Surgery, Femoral artery rupture, Child
Received: 20 Aug 2025; Accepted: 21 Oct 2025.
Copyright: © 2025 Jia, Wang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Tao Liu, 526703475@qq.com
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