Your new experience awaits. Try the new design now and help us make it even better

CASE REPORT article

Front. Surg.

Sec. Orthopedic Surgery

This article is part of the Research TopicAdvancing Orthopedic Surgery: unique Case Reports driving progressView all articles

Case Report of Acupotomy Release Combined with Manual Release Under Anesthesia for Adhesions After Unilateral Total Knee Arthroplasty in a Patient with Hemophilia A

Provisionally accepted
Wei  WangWei Wang1Xiaochan  XuXiaochan Xu1Kui  SunKui Sun2Tianyao  WangTianyao Wang2Yonghui  YangYonghui Yang2*Sanbing  WuSanbing Wu2*
  • 1Department of Emergency, Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, China
  • 2Department of Orthopedics and Traumatology, Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, China

The final, formatted version of the article will be published soon.

Patients with end-stage hemophilia often require total knee arthroplasty (TKA); however, the incidence of postoperative joint adhesions in these patients is significantly higher than that in the general population. Furthermore, due to their impaired coagulation function, the bleeding risk associated with traditional open adhesiolysis is also higher in this patient cohort than in the general population, and conservative rehabilitation therapy yields suboptimal outcomes. Thus, there is an urgent clinical need for a safe and effective intervention regimen. This study reports a 25-year-old male patient with severe hemophilia A (factor Ⅷdeficiency), whose baseline factor Ⅷactivity was 0.8%. Severe knee joint adhesions occurred 3 months after TKA, manifested as difficulty in walking, sitting, and standing. A combined treatment regimen of "perioperative precise coagulation factor replacement + ultrasound-guided acupotomy release under anesthesia + graded manual release" was adopted for the intervention of post-TKA adhesions in patients with severe hemophilia A. The results showed that this combined regimen may represent a feasible minimally invasive option for the clinical management of post-TKA adhesions in severe hemophilia A patients.

Keywords: Hemophilia A, Total knee arthroplasty (TKA), JointAdhesions, Acupotomy Release, Manual release, Coagulation Factor ReplacementTherapy

Received: 25 Sep 2025; Accepted: 31 Oct 2025.

Copyright: © 2025 Wang, Xu, Sun, Wang, Yang and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Yonghui Yang, yangyonghui@ahtcm.edu.cn
Sanbing Wu, 278451108@qq.com

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.