Frontiers in Systems Biology

Original Research

Published on 11 Jun 2026

Computational analysis and validation of UGT1A1/4 missense variants impacting tecovirimat metabolism in monkeypox patients

in Integrative Genetics and Genomics

Amro A. Abdelazim
Sameh E. Hassanein
Mohamad Maged
Nada S. Al-Theyab
Itoh Kimiko
Kotb A. Attia

Frontiers in Systems Biology

doi 10.3389/fsysb.2026.1821230

657 views

Original Research

Published on 09 Jun 2026

Glioma identification from microRNA biomarkers using machine learning

in Data and Model Integration

Rakesh Kanth Andugala
Alyson Cieslik
Maria Braoudaki
Iosif Mporas

Frontiers in Systems Biology

doi 10.3389/fsysb.2026.1771910

484 views

Original Research

Accepted on 08 Jun 2026

N-Gene and T-Gene Deregulation Networks: A data-driven causal framework for the analysis of gene interventions in cancer

in Integrative Genetics and Genomics

Frank Castel
Roberto Herrero
Jean Pierre Gómez
Gabriel Gil
Augusto Gonzalez

Frontiers in Systems Biology

Mini Review

Accepted on 08 Jun 2026

The interaction of biological network topology and mutation effects in complex trait evolution

in Integrative Systems Ecology, Evolution and Plant Science

Alexandre Gouy

Frontiers in Systems Biology

Original Research

Published on 05 Jun 2026

Prioritizing long COVID related single nucleotide polymorphisms by mining genome-wide association studies of COVID-19 susceptibility and hospitalization

in Integrative Genetics and Genomics

Zhong-Shan Cheng

Frontiers in Systems Biology

doi 10.3389/fsysb.2026.1797543

669 views

Review

Published on 04 Jun 2026

Quorum-quenching for bacterial pathogen control and health management in aquaculture: mechanisms, applications, current status and future prospects

in Integrative Systems Microbiology

Prapti Sudan
Anand Kumar
Neelesh Kumar
Satya Narayan Parida
Ajaya Kumar Rout
Prabjeet Singh
Partha Sarathi Tripathy
Bijay Kumar Behera
Pramod Kumar Pandey
Anuj Tyagi

Frontiers in Systems Biology

doi 10.3389/fsysb.2026.1861713

631 views

Review

Published on 04 Jun 2026

Multilayer network approaches to omics data integration in digital twins for cancer research

in Data and Model Integration

Hugo Chenel
Malvina Marku
Tim James
Andrei Zinovyev
Vera Pancaldi

Frontiers in Systems Biology

doi 10.3389/fsysb.2026.1776941

914 views

Original Research

Accepted on 03 Jun 2026

Improving DirectLiNGAM for High-Dimensional Microbiome Data: Roots Screening and eBIC Based Model Selection

in Data and Model Integration

Francesco Canonaco
Enzo Acerbi
Fabio Stella

Frontiers in Systems Biology

166 views

Perspective

Accepted on 02 Jun 2026

Integrating Clinical Knowledge to Preserve Clinical Coherence in Health Systems

in Systems Concepts, Theory and Policy in Biology and Medicine

Lawrence Merle Nelson

Frontiers in Systems Biology

147 views

Original Research

Published on 01 Jun 2026

Multi-OCT-SelfNet: integrating self-supervised learning with multi-source data fusion for enhanced multi-class retinal disease classification

in Data and Model Integration

Fatema E. Jannat
Sina Gholami
Jennifer I. Lim
Theodore Leng
Minhaj Nur Alam
Hamed Tabkhi

Frontiers in Systems Biology

doi 10.3389/fsysb.2026.1717398

447 views

Original Research

Accepted on 31 May 2026

Design and develop a prototype fixed column using Bacterial Cellulose and Ferric Chloride for Cr(VI) removal

in Integrative Systems Ecology, Evolution and Plant Science

Carreño Fernando Sayago
Vladimir Ballesteros Ballesteros
Angelica Maria Lozano Aguilar
Jorge Luis Nisperuza

Frontiers in Systems Biology

155 views

Original Research

Accepted on 27 May 2026

Network Analysis of Rare Single-Nucleotide Polymorphisms Suggests a Central Role for Type 17 Immune Responses in Trauma-induced, Genotypically Associated Hypo-Inflammation and Critical Illness

in Integrative Genetics and Genomics

Fayten El-Dehaibi
Ruben Zamora
Jinling Yin
Timothy Robert Billiar
Yoram Vodovotz

Frontiers in Systems Biology

213 views

Perspective

Published on 25 May 2026

Duty of Care Governance: a conceptual framework for aligning health system scale with the clinician–patient relationship

in Systems Concepts, Theory and Policy in Biology and Medicine

Lawrence Merle Nelson

Frontiers in Systems Biology

doi 10.3389/fsysb.2026.1796465

716 views

Original Research

Published on 22 May 2026

Meta-cancer phosphoproteomic analysis unveils association of Tau phosphosites with DNA damage response

in Integrative Genetics and Genomics

Tejaswini Rohinath Poojari
Leona Dcunha
Althaf Mahin
Athira Perunelly Gopalakrishnan
Mukhtar Ahmed
Pathiyil Sajini Sekhar
Samseera Ummar
Levin John
Prashant Kumar Modi
Sowmya Soman

Frontiers in Systems Biology

doi 10.3389/fsysb.2026.1819794

725 views

Original Research

Published on 20 May 2026

Toward the genetic landscape of prostate cancer in India: insights from whole-exome and low-pass whole-genome sequencing of formalin-fixed paraffin-embedded tumor tissues

in Integrative Genetics and Genomics

Soham Biswas
Bhargavi Rajarathinam
Barkha Khilwani
Gaurav Jalendra
Devendra Sharma
Maneesh Vijavargiya
Rajaguru Aradhya
Abdul S. Ansari
Nidhi Shukla
Gyaneshwer Chaubey

Frontiers in Systems Biology

doi 10.3389/fsysb.2026.1803649

1,062 views

Perspective

Accepted on 11 May 2026

BioModels Model of the Year 2024

in Data and Model Integration

Rahuman S. Malik-Sheriff
Hiroki Asari
Liesbet Geris
Henning Hermjakob
Karthik Raman
Blerta Shtylla
Maria Zimmermann-Kogadeeva

Frontiers in Systems Biology

348 views

Systematic Review

Published on 07 May 2026

Mpox coinfections and clinical manifestation in Africa: a systematic review and meta-analysis

in Translational Systems Biology and In Silico Trials

Fabrice Zobel Lekeumo Cheuyem
Chabeja Achangwa
Lionel Berthold Keubou Boukeng
Rick Tchamani
Jessica Davies
Christian Noël Malaka
Armel Evouna Mbarga

Frontiers in Systems Biology

doi 10.3389/fsysb.2026.1795422

889 views

Review

Published on 30 Apr 2026

From empirical vaccinology to predictive systems-based vaccine design: multi-omics integration, artificial intelligence, and global equity challenges

in Systems and Synthetic Immunology

Nicole Simone De Lima Coelho
Viviana Simone De Lima Coelho

Frontiers in Systems Biology

doi 10.3389/fsysb.2026.1819469

1,115 views

Review

Published on 29 Apr 2026

AI-based methods for the assessment of DNA damage and repair mechanisms

in Systems Concepts, Theory and Policy in Biology and Medicine

Paola Lecca
Michela Lecca
Adaoha Elizabeth Ihekwaba-Ndibe

Frontiers in Systems Biology

doi 10.3389/fsysb.2026.1734322

1,517 views

Original Research

Accepted on 23 Apr 2026

Optimizing Carbon Source Based on Water Temperature to Reduce Vibrio Abundance and Promote Beneficial Bacteria in Penaeus vannamei Shrimp Biofloc System in China: A preliminary study

in Integrative Systems Microbiology

Abdallah Ghonimy
Zhao Chen
Laura Susana López Greco
Fernando Dyzenchauz
Jian Li

Frontiers in Systems Biology

611 views

Original Research

Published on 22 Apr 2026

Structure and multipartite genome architecture of the mitochondrial genome in the endangered medicinal plant Fritillaria taipaiensis P. Y. Li

in Integrative Genetics and Genomics

De Xu
Jingtao Liu
Juan Huang
Qianqian Ma
Tao Wang
Zhou Xie
Xue Liu
Liang Fu

Frontiers in Systems Biology

doi 10.3389/fsysb.2026.1708877

893 views

Original Research

Published on 09 Apr 2026

Design of synthetic selenopeptides with antioxidant activity for the treatment of XP and non-melanoma skin cancer

in Translational Systems Biology and In Silico Trials

Arthur Alves Coelho
Eduarda Pereira Soares Dias
André Kipnis

Frontiers in Systems Biology

doi 10.3389/fsysb.2026.1686085

1,256 views

General Commentary

Published on 30 Mar 2026

Commentary: GETgene-AI: a framework for prioritizing actionable cancer drug targets

in Multiscale Mechanistic Modeling

Ling Yin

Frontiers in Systems Biology

doi 10.3389/fsysb.2026.1793501

1,198 views

Opinion

Published on 24 Mar 2026

Systems biology in the era of AI: “winter” or “evolution”?

in Systems Concepts, Theory and Policy in Biology and Medicine

Mohamed Helmy
Kumar Selvarajoo

Frontiers in Systems Biology

doi 10.3389/fsysb.2026.1818525

1,835 views

196 articles

articles

Computational analysis and validation of UGT1A1/4 missense variants impacting tecovirimat metabolism in monkeypox patients

Glioma identification from microRNA biomarkers using machine learning

N-Gene and T-Gene Deregulation Networks: A data-driven causal framework for the analysis of gene interventions in cancer

The interaction of biological network topology and mutation effects in complex trait evolution

Prioritizing long COVID related single nucleotide polymorphisms by mining genome-wide association studies of COVID-19 susceptibility and hospitalization

Quorum-quenching for bacterial pathogen control and health management in aquaculture: mechanisms, applications, current status and future prospects

Multilayer network approaches to omics data integration in digital twins for cancer research

Improving DirectLiNGAM for High-Dimensional Microbiome Data: Roots Screening and eBIC Based Model Selection

Integrating Clinical Knowledge to Preserve Clinical Coherence in Health Systems

Multi-OCT-SelfNet: integrating self-supervised learning with multi-source data fusion for enhanced multi-class retinal disease classification

Design and develop a prototype fixed column using Bacterial Cellulose and Ferric Chloride for Cr(VI) removal

Network Analysis of Rare Single-Nucleotide Polymorphisms Suggests a Central Role for Type 17 Immune Responses in Trauma-induced, Genotypically Associated Hypo-Inflammation and Critical Illness

Duty of Care Governance: a conceptual framework for aligning health system scale with the clinician–patient relationship

Meta-cancer phosphoproteomic analysis unveils association of Tau phosphosites with DNA damage response

Toward the genetic landscape of prostate cancer in India: insights from whole-exome and low-pass whole-genome sequencing of formalin-fixed paraffin-embedded tumor tissues

BioModels Model of the Year 2024

Mpox coinfections and clinical manifestation in Africa: a systematic review and meta-analysis

From empirical vaccinology to predictive systems-based vaccine design: multi-omics integration, artificial intelligence, and global equity challenges

AI-based methods for the assessment of DNA damage and repair mechanisms

Optimizing Carbon Source Based on Water Temperature to Reduce Vibrio Abundance and Promote Beneficial Bacteria in Penaeus vannamei Shrimp Biofloc System in China: A preliminary study

Structure and multipartite genome architecture of the mitochondrial genome in the endangered medicinal plant Fritillaria taipaiensis P. Y. Li

Design of synthetic selenopeptides with antioxidant activity for the treatment of XP and non-melanoma skin cancer

Commentary: GETgene-AI: a framework for prioritizing actionable cancer drug targets

Systems biology in the era of AI: “winter” or “evolution”?