Frontiers in Systems Biology

Original Research

Published on 21 May 2025

Mathematical modeling of pharmacokinetics and pharmacodynamics of losartan in relation to CYP2C9 allele variants

in Multiscale Mechanistic Modeling

Dmitry Babaev
Elena Kutumova
Fedor Kolpakov

Frontiers in Systems Biology

doi 10.3389/fsysb.2025.1504077

2,569 views
2 citations

Opinion

Published on 29 Apr 2025

Biotechnology systems engineering: preparing the next generation of bioengineers

in Systems Concepts, Theory and Policy in Biology and Medicine

Sebastián Espinel-Ríos

Frontiers in Systems Biology

doi 10.3389/fsysb.2025.1583534

14,469 views

Review

Published on 16 Apr 2025

The role of probiotics, prebiotics, and synbiotics in the treatment of inflammatory bowel diseases: an overview of recent clinical trials

in Integrative Systems Microbiology

Fayez Yassine
Adam Najm
Melhem Bilen

Frontiers in Systems Biology

doi 10.3389/fsysb.2025.1561047

10,003 views
7 citations

Specialty Grand Challenge

Published on 13 Mar 2025

Scientia machina: a proposed conceptual framework for a technology-accelerated system of biomedical science

in Systems Concepts, Theory and Policy in Biology and Medicine

Sean T. Manion

Frontiers in Systems Biology

doi 10.3389/fsysb.2025.1576989

2,522 views

Review

Published on 07 Jan 2025

A multi-omics strategy to understand PASC through the RECOVER cohorts: a paradigm for a systems biology approach to the study of chronic conditions

in Translational Systems Biology and In Silico Trials

Jun Sun
Masanori Aikawa
Hassan Ashktorab
Noam D. Beckmann
Michael L. Enger
Joaquin M. Espinosa
Xiaowu Gai
Benjamin D. Horne
Paul Keim
Jessica Lasky-Su

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1422384

6,597 views
3 citations

Original Research

Published on 03 Jan 2025

Improvement in the prediction power of an astrocyte genome-scale metabolic model using multi-omic data

in Data and Model Integration

Andrea Angarita-Rodríguez
Nicolás Mendoza-Mejía
Janneth González
Jason Papin
Andrés Felipe Aristizábal
Andrés Pinzón

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1500710

2,947 views

Original Research

Published on 12 Dec 2024

Immune disease dialogue of chemokine-based cell communications as revealed by single-cell RNA sequencing meta-analysis

in Systems and Synthetic Immunology

Mouly F. Rahman
Andre H. Kurlovs
Munender Vodnala
Elamaran Meibalan
Terry K. Means
Nima Nouri
Emanuele de Rinaldis
Virginia Savova

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1466368

4,883 views
2 citations

Methods

Published on 18 Nov 2024

An exploration of testing genetic associations using goodness-of-fit statistics based on deep ReLU neural networks

in Integrative Genetics and Genomics

Xiaoxi Shen
Xiaoming Wang

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1460369

1,593 views
1 citation

Mini Review

Published on 13 Nov 2024

Interplay of circular RNAs in gastric cancer - a systematic review

in Integrative Genetics and Genomics

Dipanjan Guha
Jit Mondal
Anirban Nandy
Sima Biswas
Angshuman Bagchi

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1497510

1,621 views
2 citations

Specialty Grand Challenge

Published on 06 Nov 2024

Bridging complexity through integrative systems neuroscience

in Integrative Systems Neuroscience

Eric H. Chang

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1487298

4,447 views
1 citation

Original Research

Published on 15 Oct 2024

Intertwined roles for GDF-15, HMGB1, and MIG/CXCL9 in Pediatric Acute Liver Failure

in Data and Model Integration

Ruben Zamora
Jinling Yin
Derek Barclay
James E. Squires
Yoram Vodovotz

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1470000

1,997 views
2 citations

Methods

Published on 03 Oct 2024

Spectral expansion methods for prediction uncertainty quantification in systems biology

in Data and Model Integration

Anna Deneer
Jaap Molenaar
Christian Fleck

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1419809

1,820 views
2 citations

Methods

Published on 12 Sep 2024

Building virtual patients using simulation-based inference

in Translational Systems Biology and In Silico Trials

Nathalie Paul
Venetia Karamitsou
Clemens Giegerich
Afshin Sadeghi
Moritz Lücke
Britta Wagenhuber
Alexander Kister
Markus Rehberg

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1444912

3,941 views
1 citation

Original Research

Published on 02 Sep 2024

Accessible Type 2 diabetes medication through stable expression of Exendin-4 in Saccharomyces cerevisiae

in Data and Model Integration

Gia Balius
Kiana Imani
Zoë Petroff
Elizabeth Beer
Thiago Brasileiro Feitosa
Nathan Mccall
Lauren Paule
Neo Yixuan Peng
Joanne Shen
Vidhata Singh

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1283371

4,123 views
1 citation

Original Research

Published on 29 Aug 2024

A multi-scale semi-mechanistic CK/PD model for CAR T-cell therapy

in Multiscale Mechanistic Modeling

Sarah Minucci
Scott Gruver
Kalyanasundaram Subramanian
Marissa Renardy

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1380018

3,887 views
2 citations

Original Research

Published on 14 Aug 2024

First evidence for temperature’s influence on the enrichment, assembly, and activity of polyhydroxyalkanoate-synthesizing mixed microbial communities

in Integrative Systems Microbiology

Anna Trego
Tania Palmeiro-Sánchez
Alison Graham
Umer Zeeshan Ijaz
Vincent O’Flaherty

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1375472

2,827 views
2 citations

Original Research

Published on 06 Aug 2024

Modeling uncertainty: the impact of noise in T cell differentiation

in Systems and Synthetic Immunology

David Martínez-Méndez
Carlos Villarreal
Leonor Huerta

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1412931

2,378 views
2 citations

Review

Published on 02 Aug 2024

The rise of scientific machine learning: a perspective on combining mechanistic modelling with machine learning for systems biology

in Data and Model Integration

Ben Noordijk
Monica L. Garcia Gomez
Kirsten H. W. J. ten Tusscher
Dick de Ridder
Aalt D. J. van Dijk
Robert W. Smith

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1407994

11,266 views
25 citations

Perspective

Published on 24 Jul 2024

Transporter annotations are holding up progress in metabolic modeling

in Data and Model Integration

John Casey
Brian Bennion
Patrik D’haeseleer
Jeffrey Kimbrel
Gianna Marschmann
Ali Navid

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1394084

3,613 views
10 citations

Perspective

Published on 17 Jul 2024

Life’s building blocks: the modular path to multiscale complexity

in Multiscale Mechanistic Modeling

Saúl Huitzil
Cristián Huepe

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1417800

3,929 views
4 citations

Perspective

Published on 12 Jul 2024

Coupling quantitative systems pharmacology modelling to machine learning and artificial intelligence for drug development: its pAIns and gAIns

in Translational Systems Biology and In Silico Trials

Núria Folguera-Blasco
Florencia A. T. Boshier
Aydar Uatay
Cesar Pichardo-Almarza
Massimo Lai
Jacopo Biasetti
Richard Dearden
Megan Gibbs
Holly Kimko

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1380685

5,790 views
6 citations

Original Research

Published on 04 Jul 2024

Predicting chronic responses to calcium channel blockade with a virtual population of African Americans with hypertensive chronic kidney disease

in Translational Systems Biology and In Silico Trials

John S. Clemmer
W. Andrew Pruett
Robert L. Hester

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1327357

2,521 views
1 citation

Technology and Code

Published on 17 Jun 2024

PdPANA: phagemid display as peptide array for neutralizing antibodies, an engineered in silico vaccine candidate against COVID-19

in Translational Systems Biology and In Silico Trials

Javier Uzcátegui
Khaleel Mullah
Daniel Buvat de Virgini
Andrés Mendoza
Rafael Urdaneta
Alejandra Naranjo

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1309891

2,771 views

Specialty Grand Challenge

Published on 17 Jun 2024

Specialty grand challenge: how can we use integrative approaches to understand microbial community dynamics?

in Integrative Systems Microbiology

Umer Zeeshan Ijaz
Aqsa Ameer
Farrukh Saleem
Farzana Gul
Ciara Keating
Sundus Javed

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1432791

3,273 views
4 citations

169 articles

articles

Mathematical modeling of pharmacokinetics and pharmacodynamics of losartan in relation to CYP2C9 allele variants

Biotechnology systems engineering: preparing the next generation of bioengineers

The role of probiotics, prebiotics, and synbiotics in the treatment of inflammatory bowel diseases: an overview of recent clinical trials

Scientia machina: a proposed conceptual framework for a technology-accelerated system of biomedical science

A multi-omics strategy to understand PASC through the RECOVER cohorts: a paradigm for a systems biology approach to the study of chronic conditions

Improvement in the prediction power of an astrocyte genome-scale metabolic model using multi-omic data

Immune disease dialogue of chemokine-based cell communications as revealed by single-cell RNA sequencing meta-analysis

An exploration of testing genetic associations using goodness-of-fit statistics based on deep ReLU neural networks

Interplay of circular RNAs in gastric cancer - a systematic review

Bridging complexity through integrative systems neuroscience

Intertwined roles for GDF-15, HMGB1, and MIG/CXCL9 in Pediatric Acute Liver Failure

Spectral expansion methods for prediction uncertainty quantification in systems biology

Building virtual patients using simulation-based inference

Accessible Type 2 diabetes medication through stable expression of Exendin-4 in Saccharomyces cerevisiae

A multi-scale semi-mechanistic CK/PD model for CAR T-cell therapy

First evidence for temperature’s influence on the enrichment, assembly, and activity of polyhydroxyalkanoate-synthesizing mixed microbial communities

Modeling uncertainty: the impact of noise in T cell differentiation

The rise of scientific machine learning: a perspective on combining mechanistic modelling with machine learning for systems biology

Transporter annotations are holding up progress in metabolic modeling

Life’s building blocks: the modular path to multiscale complexity

Coupling quantitative systems pharmacology modelling to machine learning and artificial intelligence for drug development: its pAIns and gAIns

Predicting chronic responses to calcium channel blockade with a virtual population of African Americans with hypertensive chronic kidney disease

PdPANA: phagemid display as peptide array for neutralizing antibodies, an engineered in silico vaccine candidate against COVID-19

Specialty grand challenge: how can we use integrative approaches to understand microbial community dynamics?