Frontiers in Systems Biology

Original Research

Published on 06 Aug 2024

Modeling uncertainty: the impact of noise in T cell differentiation

in Systems and Synthetic Immunology

David Martínez-Méndez
Carlos Villarreal
Leonor Huerta

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1412931

968 views
2 citations

Review

Published on 02 Aug 2024

The rise of scientific machine learning: a perspective on combining mechanistic modelling with machine learning for systems biology

in Data and Model Integration

Ben Noordijk
Monica L. Garcia Gomez
Kirsten H. W. J. ten Tusscher
Dick de Ridder
Aalt D. J. van Dijk
Robert W. Smith

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1407994

4,783 views
4 citations

Perspective

Published on 24 Jul 2024

Transporter annotations are holding up progress in metabolic modeling

in Data and Model Integration

John Casey
Brian Bennion
Patrik D’haeseleer
Jeffrey Kimbrel
Gianna Marschmann
Ali Navid

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1394084

1,696 views
4 citations

Perspective

Published on 17 Jul 2024

Life’s building blocks: the modular path to multiscale complexity

in Multiscale Mechanistic Modeling

Saúl Huitzil
Cristián Huepe

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1417800

1,462 views
1 citation

Perspective

Published on 12 Jul 2024

Coupling quantitative systems pharmacology modelling to machine learning and artificial intelligence for drug development: its pAIns and gAIns

in Translational Systems Biology and In Silico Trials

Núria Folguera-Blasco
Florencia A. T. Boshier
Aydar Uatay
Cesar Pichardo-Almarza
Massimo Lai
Jacopo Biasetti
Richard Dearden
Megan Gibbs
Holly Kimko

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1380685

2,607 views

Original Research

Published on 04 Jul 2024

Predicting chronic responses to calcium channel blockade with a virtual population of African Americans with hypertensive chronic kidney disease

in Translational Systems Biology and In Silico Trials

John S. Clemmer
W. Andrew Pruett
Robert L. Hester

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1327357

1,219 views
1 citation

Technology and Code

Published on 17 Jun 2024

PdPANA: phagemid display as peptide array for neutralizing antibodies, an engineered in silico vaccine candidate against COVID-19

in Translational Systems Biology and In Silico Trials

Javier Uzcátegui
Khaleel Mullah
Daniel Buvat de Virgini
Andrés Mendoza
Rafael Urdaneta
Alejandra Naranjo

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1309891

1,593 views

Specialty Grand Challenge

Published on 17 Jun 2024

Specialty grand challenge: how can we use integrative approaches to understand microbial community dynamics?

in Integrative Systems Microbiology

Umer Zeeshan Ijaz
Aqsa Ameer
Farrukh Saleem
Farzana Gul
Ciara Keating
Sundus Javed

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1432791

1,732 views
3 citations

Original Research

Published on 07 Jun 2024

Building an Adverse Outcome Pathway network for COVID-19

in Systems and Synthetic Immunology

Penny Nymark
Laure-Alix Clerbaux
Maria-João Amorim
Christos Andronis
Francesca de Bernardi
Gillina F. G. Bezemer
Sandra Coecke
Felicity N. E. Gavins
Daniel Jacobson
Eftychia Lekka

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1384481

1,379 views

Mini Review

Published on 03 Jun 2024

De novo prediction of functional effects of genetic variants from DNA sequences based on context-specific molecular information

in Integrative Genetics and Genomics

Jiaxin Yang
Sikta Das Adhikari
Hao Wang
Binbin Huang
Wenjie Qi
Yuehua Cui
Jianrong Wang

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1402664

1,749 views
1 citation

Original Research

Published on 30 May 2024

Surface-displayed silicatein-α enzyme in bioengineered E. coli enables biocementation and silica mineralization

in Data and Model Integration

Toriana N. Vigil
Nikolas K. Schwendeman
Melanie L. M. Grogger
Victoria L. Morrison
Margaret C. Warner
Nathaniel B. Bone
Morgan T. Vance
David C. Morris
Kristi McElmurry
Bryan W. Berger

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1377188

2,163 views

Review

Published on 29 Apr 2024

Crosstalking with dendritic cells: a path to engineer advanced T Cell immunotherapy

in Systems and Synthetic Immunology

Sogand Schafer
Kaige Chen
Leyuan Ma

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1372995

3,165 views
1 citation

Original Research

Published on 25 Apr 2024

Elucidating a genomic signature associated with behavioral and executive function after moderate to severe pediatric TBI: a systems biology informed approach

in Integrative Genetics and Genomics

Brad G. Kurowski
Amery Treble-Barna
Valentina Pilipenko
Lisa J. Martin
Anil G. Jegga
Aimee E. Miley
Nanhua Zhang
Anthony Fabio
Ranjit S. Chima
Anna-Lynne R. Adlam

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1293265

1,223 views

Technology and Code

Published on 18 Apr 2024

Context-aware knowledge selection and reliable model recommendation with ACCORDION

in Data and Model Integration

Yasmine Ahmed
Cheryl A. Telmer
Gaoxiang Zhou
Natasa Miskov-Zivanov

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1308292

989 views
6 citations

Review

Published on 09 Apr 2024

A review of mathematical modeling of bone remodeling from a systems biology perspective

in Multiscale Mechanistic Modeling

Carley V. Cook
Ariel M. Lighty
Brenda J. Smith
Ashlee N. Ford Versypt

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1368555

3,743 views
6 citations

Original Research

Published on 09 Apr 2024

Forecasting SARS-CoV-2 spike protein evolution from small data by deep learning and regression

in Data and Model Integration

Samuel King
Xinyi E. Chen
Sarah W. S. Ng
Kimia Rostin
Samuel V. Hahn
Tylo Roberts
Janella C. Schwab
Parneet Sekhon
Madina Kagieva
Taylor Reilly

Frontiers in Systems Biology

doi 10.3389/fsysb.2024.1284668

3,172 views
2 citations