Research Topic

Molecular Evolution: You Learn from Your Mistakes

About this Research Topic

Who would have ever thought that to make mistakes can be a good thing? Yet it is now well known that error prone polymerases can be used precisely because they ensure a low fidelity transcription of the genetic information thus providing a unique tool to obtain information that in some way, simulate the ...

Who would have ever thought that to make mistakes can be a good thing? Yet it is now well known that error prone polymerases can be used precisely because they ensure a low fidelity transcription of the genetic information thus providing a unique tool to obtain information that in some way, simulate the course of evolution.

Rather than being unwanted, mutations are allowed and welcome to be able to create entire molecular evolution libraries that allow divergence of the primary code. Turning back to the last 5-10 years molecular evolution has been the basis of interesting and very different applications, from enzyme optimization to the study of evolutionary trajectories.

In this Research Topic, we wish to highlight and promote the use of powerful tools for molecular evolution and we wish that the people who will contribute to it will propose as many new applications and perspectives.

This Research Topic is focused on in vitro evolution from an experimental and a computational analysis perspective and we encourage the submission of relevant scientific articles or reviews/perspectives. Suggested topics are:

· (i) Novel and classical techniques for molecular evolution
· (ii) Computational models of natural and man-made evolution
· (iii) Automation for in vitro evolution
· (iv) Development of integrative approaches for the evolution of biological units
· (v) Evolutionary data analysis
· (vi) Determination of structural information by muatgenesis
· (vii) Studies on the trajectories of evolution using in vitro evolution
· (viii) Databases or large collections of mutants obtained by molecular evolution
· (ix) Other topics related to the field


Note from the editorial office: we would like to acknowledge Marco Fantini for initiating and coordinating this project. The peer review of submitted manuscripts will be handled by the other Topic Editors or members of the Associate Editorial Board.


Keywords: molecular evolution, mutagenesis, in vitro evolution, evolutionary biology, structural biology, mutational data analysis


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

10 June 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

10 June 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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