About this Research Topic
Endophenotypes are quantitative neurobiological traits that provide a powerful toolkit for studying the genomic and neural substrates of complex neuropsychiatric disorders, in particular, schizophrenia, autism, depression etc. However, despite the considerable amount of accumulated data, our knowledge about the specificity of different endophenotypes for various neuropsychiatric pathologies is limited. Endophenotypes related to dysfunctions of inhibition, different stages of attention and executive control, were reported to be inheritable and intrinsic for schizophrenia. Sensory and sensory-motor gating, cognitive evoked potentials, oculomotor control (including smooth pursuit eye movement and antisaccades) are among the most valid neurophysiological endophenotypes of schizophrenia spectrum disorders. However, some of these dysfunctions have been observed also in ADHD, some types of bipolar and anxiety disorders, autism, depression, Alzheimer’s disease, Parkinson's disease, etc.
The comparative analysis of heritability and state-relevance versus trait-relevance of these deficits under different pathological conditions has not yet been conducted. Neuroimaging studies revealed that despite the partial overlap, the patterns of neuronal substrates of various neuropsychiatric disorders are characterized by significant specificity. Accordingly, the differences in the patterns of neurophysiological dysfunctions between cohorts of patients with various neuropsychiatric diagnoses as well as between subgroups within heterogeneous diseases (in particular, schizophrenia) can be expected. Identification of such specific patterns and their genomic associations can provide new opportunities for understanding, modeling, identifying the risk and treating common complex neuropsychiatric disorders.
With this Research Topic we aim to bringing together different studies on the comparative analysis of neurophysiological endophenotypes related to attention, inhibition and executive functions in different mental disorders as well as in the subgroups within heterogeneous neuropsychiatric diseases. We welcome submissions in the form of:
• Original Researcher
All contributions addressing both genomic associations of neurophysiological dysfunctions and their correlations with personality traits under different psychopathology conditions will be welcome. The impact analysis of the impact of the experimental protocols (especially, parameters of stimulation) on the tests performance in different groups of patients is of great interest. AlsoLastly, the pattern studies of the patterns of listed neurophysiological dysfunctions in different translational animal models of common complex neuropsychiatric disorders are also suitable.
Keywords: Endophenotypes, Attention, Inhibition, Executive Control, Working Memory, Sensory Gating, Sensory-Motor Gating, Schizophrenia, Bipolar Disorder, Depression, Anxiety Disorder, ADHD, Autistic Spectrum Disorder
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