Expert Opinions in Genomic Analysis

This collection explores the rapidly evolving landscape of microbiome and multi-omics data reuse, emphasizing both the challenges faced and the opportunities ahead. Survey data from over 700 researchers highlight critical barriers including complex metadata management, bioinformatics bottlenecks, and repository submission hurdles, with bioinformatics processing identified as particularly time-consuming. Ethical, technical, and infrastructural constraints further complicate the effective sharing and reutilization of genomic and metagenomic datasets, underscoring the urgent need for standardized protocols, better metadata practices, and collaborative frameworks. Contributions from international alliances such as IMMSA and GSC underscore the importance of multifaceted strategies that integrate transparency, accessibility, and ethical guidelines to foster responsible and innovative data-driven science. Also spotlighted are emerging computational techniques, notably the application of large language models (LLMs) to protein modeling and design, which hold promise for transformative advances but also introduce new challenges requiring ongoing community engagement and collaboration. Collectively, these articles advocate for actionable recommendations and cross-disciplinary efforts to realize the full potential of open science in the microbiome and genomics domains.
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This Research Topic aims to promote, debate or to change the perspective on research in various areas of the field of genomic analysis.

The collection welcomes contributions expanding thoughts and perspectives on the current challenges, latest discoveries, recent advances, and future perspectives in this field. In particular, we welcome the submission of Opinion and Perspective articles that provide editorialized analysis related but not limited to bioinformatics applied to single cell genomics, precision medicine, AI in genomics, metagenomics, ancestral genome reconstruction, and genome editing.

For more information regarding the article types supported by the journal, please check here: https://www.frontiersin.org/journals/bioinformatics/for-authors/article-types

Keywords: opinion, perspective, bioinformatics, genome analysis, single cell genomics, precision medicine, ancestral genome reconstruction, genome editing

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.