About this Research Topic
Systemic immunity, sports medicine, and exercise-induced immunomodulation are actively studied research areas that have a significant impact on health, fitness, longevity, and overall wellness. Exercise-induced immunomodulation may mediate some of the beneficial effects of regular exercise on health and disease resistance. Regular exercise also leads to more durable changes in immunity, characterized by enhanced resistance to infection through higher levels of antibodies and other effector molecules produced by B lymphocytes, as well as increased numbers or activity of natural killer cells. The mechanism leading to these changes mainly includes the change of cytokine production pattern, especially the increase of IL-6, IL-1β and TNFα, chemokines such as CXCL8/IL-8; Growth factors such as GM-CSF; Adhesion molecules involved in leukocyte migration, such as ICAM-1; Reactive oxygen species (ROS) -induced oxidative stress response during exercise; Epigenetic modification caused by DNA methylation at specific sites in gene promoter regions; the immune response caused by injured tissue microenvironment, implant or postoperative complications. So it makes sense to explore the evolution of molecular and osteocyte circuits in order to better understand their relationship with systemic immunity and immune homeostasis through quantitative dynamic modeling.
For this topic, we will explore the new mechanisms by which different types of exercise affect evolutionary systems immunology, the new effects of different modes and intensities on immune cell populations, and the new findings of epigenetics in regulating the immune response induced by exercise, injured tissue microenvironment, implant or postoperative complications.
We encourage researchers to submit high-quality observational, experimental, and review studies that provide evidence on biomechanics, physiology, and the underlying mechanisms of movement and tissue microenvironment. High-quality RCTS investigating the effects of exercise on immune regulation are particularly welcome. We are also interested in literature reviews, longitudinal cohort studies, or systematic reviews with meta-analyses.
For this topic, we will explore the new mechanisms by which different types of exercise affect evolutionary systems immunology, the new effects of different modes and intensities on immune cell populations, and the new findings of epigenetics in regulating the immune response induced by exercise, injured tissue microenvironment, implant or postoperative complications.
We encourage researchers to submit high-quality observational, experimental, and review studies that provide evidence on biomechanics, physiology, and the underlying mechanisms of movement and tissue microenvironment. High-quality RCTS investigating the effects of exercise on immune regulation are particularly welcome. We are also interested in literature reviews, longitudinal cohort studies, or systematic reviews with meta-analyses.
Keywords: • Sports medicine, Exercise training, Immune modulation, Osteoimmunology, Osteoclast, Osteoblast, Osteocyte, Cytokines, Growth factors, Chemokines, Adhesion molecules, Epigenetic modification, Reactive oxygen species
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
