Advance in Bioprocessing Design for Platform Chemicals and Biofuels Innovations

Consolidated bioprocessing is regarded as a promising solution to enhance sustainability across energy, environmental, and natural resource sectors. Bioprocess engineering for biomass valorization, synthetic microorganisms, and sustainability modelling are the main components of integrated biorefinery system development. Such biomass-to-bioproduct pipelines have the potential to initiate a circular bioeconomy, foster waste reduction practices, and contribute significantly to global decarbonization efforts. However, the commercialization of biorefineries faces challenges due to technology complexity, costly processing, feedstock uncertainty, and biomass-derived inhibitory effects on microbial cultures. To date, the integration of metabolic engineering and biomass deconstruction has emerged as a hot topic. This approach aims to facilitate platform chemical production through the construction of bioprocessing pathways, opening up exciting possibilities for creating a diverse range of valuable products from renewable biomass resources. Therefore, advanced research in synthetic biology, bioproduct innovation, and bioprocessing design for industrial practices is essential for securing the long-term sustainability of integrated biorefineries.

Bioprocessing innovation, aiming to expand the range of bioproduct conversion from renewable feedstock, has garnered significant attention recently. To have a viable bioprocessing system, microorganism engineering and process design play important roles in producing multiple products from a single pipeline. The goal of this Research Topic is to have impactful perspectives on advanced biorefinery improvement, encompassing biomass valorization through microbial cultures, metabolic pathway construction for high-value bioproduct synthesis, and intelligent processing design for the development of future biorefinery industries. According to these areas of research, the future outlook on potential economic cost and environmental viability of consolidated bioprocessing can be conceptualized.



This Research Topic seeks high-quality research focusing on novel bioprocessing design and technology development for high-value platform chemical and biofuel productions. Topics include but are not limited to:

• Synthetic microorganisms
• Metabolic engineering
• Biocatalysts technology for bioproduct productions
• Bioprocessing design for industrial practices
• Biomass valorizations
• Bioproduct innovations
• Bioprocessing modelling
• Microbial engineering for bioproduct production

Keywords: Synthetic biology, Sustainable biorefineries, Platform chemicals, Biofuels, Biomass-to-bioproduct pipelines, Biomass valorization, Microbial conversion, Microbial engineering for bioproduct production

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.