Anaphylaxis Challenges: Idiopathic and Rare Causes

The main first step in managing anaphylaxis is establishing a correct diagnosis. Many factors concerning definition, diagnostic criteria, and lack of confirmatory testing, makes the diagnosis a challenge, not only to the treating or first line medical responders but also to the allergologists who are investigating the cause. Idiopathic, unusual presentations and rare causes might be wrongly interpreted leading to misdiagnosis. A lack of awareness as well as geographical and social inequalities create additional challenges.

This Research Topic aims to allow participants to provide their experience in manuscripts that can address challenges faced in real life. Manuscripts can include opinion and local experience using the current definition and diagnostic criteria, as well as studies and research conducted in respect to testing, diagnosis, and management.

Suitable articles include but are not limited to case reports, case studies, original research articles, mini reviews, reviews, or systematic reviews, opinion articles, methodology or study protocol, or perspectives with a focus on:

• Epidemiology and clinical manifestations
• Current understanding and limitations
• Manifestations of some rare causes or idiopathic and development of diagnostic pathway
• Methodology to improve guideline, testing, or investigation
• Challenges in clinical outcome and management
• Clinical/ psychological aspects
• Quality of life and surveys
• Geographical/ social/ habits related factors
• Local experience, local consensus

All article types accepted by Frontiers in Allergy are welcome.

Keywords: Anaphylaxis, diagnostic challenges, allergic reactions, systemic reactions, rare causes, idiopathic anaphylaxis

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.