Metabolomics in Cardiovascular Diseases: Diagnosis, Prognosis, Therapy Targets and Mechanisms

The imbalance of endogenous metabolites in proportion, concentration, and metabolic flux caused by myocardial metabolic disorders in various cardiovascular disease processes can be reflected in samples such as blood, urine, and tissue. Using metabolomics methods to study the changes in metabolic spectra over time can help provide complete information on overall function during cardiovascular disease processes. Metabolomics can identify potential biomarkers of cardiovascular disease and make early diagnosis and prognosis judgments through screening, qualitative, quantitative, and validation analysis of metabolite levels in the body. In addition, during the occurrence and development of many cardiovascular diseases, there are metabolic disorders in cardiomyocytes, including energy metabolism, glycolysis, and fatty acid metabolism, as well as significant changes in the expression of metabolic substrates. There may be potential therapeutic targets among them, and the mechanisms need to be explored and elucidated.

The goal of this Research Topic is to provide a forum to advance the contribution of metabolomics to the occurrence and development of cardiovascular diseases, thereby exploring various potential biomarkers and therapeutic targets, and providing assistance for the diagnosis and treatment of cardiovascular diseases.

We welcome submissions on the following topics, but are not limited to:
- Discovery of plasma biomarkers for cardiovascular diseases diagnosis
- Analyzing the biochemical metabolic status in cardiovascular disease through metabolic regulation networks
- Clarifying the etiology and mechanism of cardiovascular diseases based on different metabolic characteristics
- Exploring potential functional small molecule metabolism for cardiovascular disease
- Combining other multi omics analyses to deeply analyze the pathophysiological mechanisms
- Metabolomics and drug efficacy and toxicology

Keywords: metabolomics, cardiovascular disease, biomarkers, therapy targets, mechanisms

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.