JAK-STAT Signaling Pathway and Rheumatic Diseases

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Articles

ORIGINAL RESEARCH

Published on 09 Dec 2025

Using mass cytometry to probe the STAT signaling landscape in circulating immune cells in Rheumatoid Arthritis uncovers signaling dysregulation and correlation with disease activity

Claudia Macaubas
Batuhan Bayram
Noor Hussein
Astraea Jager
Kara L. Davis
Jonathan Graf
Mary Nakamura
Devy Zisman
Elizabeth D. Mellins

doi 10.3389/fmed.2025.1622537

1,109 views

PERSPECTIVE

Published on 28 Nov 2025

Therapeutic potential of peptidomimetics of suppressors of cytokine signaling (SOCS) proteins in rheumatic disorders

Alessia Cugudda
Daniela Marasco

doi 10.3389/fmed.2025.1708293

685 views

ORIGINAL RESEARCH

Published on 08 Oct 2025

Macrophage PTP1B regulates mitochondrial dynamics via the JAK2/STAT3-OPA1 axis and activates the cGAS/STING signaling pathway

Xuefeng Lei
Diandian Qian
Wenzheng Zhang
Bin’an Zhao
Yabin Li
Hua Hao
Jing Yuan
Le Zhao
Centao Liu

doi 10.3389/fimmu.2025.1644289

2,234 views

CASE REPORT

Published on 02 Sep 2025

Case Report: JAK inhibitors for the treatment of anti-melanoma differentiation-associated gene 5-positive dermatomyositis with spontaneous pneumomediastinum

Xin Yang
Xiaoguang Cui
Xueyi Li

doi 10.3389/fmed.2025.1642484

1,250 views

ORIGINAL RESEARCH

Published on 28 Mar 2025

Interindividual variability and its impact on the effectiveness of Janus kinase inhibitors in rheumatoid arthritis treatment

Cristina Martinez-Molina
Silvia Vidal
Cesar Diaz-Torne
Hye S. Park
Hèctor Corominas

doi 10.3389/fmed.2025.1512501

2,526 views
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Rheumatology

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