Chromatin Modifications and Gene Expression: From Mechanisms to Therapeutic Implications in Disease

Within the realm of genetic regulation, chromatin modifications such as histone methylation and acetylation play pivotal roles in the transcriptional control of genes. Disruptions in these processes are increasingly implicated in a variety of pathologies, including cancers, neurological diseases, and developmental disorders. The intricate network of these modifications suggests a delicate balance that, when disturbed, dramatically influences disease onset and progression.

This Research Topic aims to deepen our understanding of how chromatin modifications control gene expression and their subsequent impact on disease mechanics and treatment potential. By exploring the pathways through which modifications like methylation and acetylation interact with genetic material, we can uncover new facets of disease development and potential intervention points for therapeutic approaches.

To gather further insights into these complex interactions, we welcome articles addressing, but not limited to, the following themes:

• Mechanistic studies on specific chromatin modifications affecting gene expression.

• Examination of chromatin modifications in disease progression and development.

• Identification and roles of crucial chromatin modifiers in various diseases.

• Development of therapeutic strategies targeting chromatin alterations.

• Innovative methods for analyzing chromatin dynamics and modification patterns.

By focusing on these aspects, the research community can advance our comprehension of chromatin's regulatory roles and establish foundational knowledge for future therapeutic innovations.